A visual rating scale for cingulate island sign on 18F-FDG-PET to differentiate dementia with Lewy bodies and Alzheimer's disease
Valid diagnosis of dementia with Lewy bodies (DLB) is essential to establish appropriate treatment and care. However, the diagnostic accuracy is complicated by clinical and pathological overlap with Alzheimer's disease (AD). Cingulate island sign (CIS), defined as sparing of posterior cingulate cortex (PCC) relative to precuneus and cuneus on 18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG-PET), is included in the revised diagnostic DLB criteria. There are no guidelines for the visual grading of CIS, although visual rating is a fast-applicable method in a clinical setting.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Le Gjerum, Kristian Steen Frederiksen, Otto M ølby Henriksen, Ian Law, Lasse Anderberg, Birgitte Bo Andersen, Eva Bjerregaard, Anne-Mette Hejl, Peter Høgh, Steen Gregers Hasselbalch Source Type: research