Cancers, Vol. 12, Pages 47: Individualizing Follow-Up Strategies in High-Grade Soft Tissue Sarcoma with Flexible Parametric Competing Risk Regression Models

Cancers, Vol. 12, Pages 47: Individualizing Follow-Up Strategies in High-Grade Soft Tissue Sarcoma with Flexible Parametric Competing Risk Regression Models Cancers doi: 10.3390/cancers12010047 Authors: Smolle Sande Callegaro Wunder Hayes Leitner Bergovec Tunn van Praag Fiocco Panotopoulos Willegger Windhager Dijkstra van Houdt Riedl Stotz Gerger Pichler Stöger Liegl-Atzwanger Smolle Andreou Leithner Gronchi Haas Szkandera Currently, patients with extremity soft tissue sarcoma (eSTS) who have undergone curative resection are followed up by a heuristic approach, not covering individual patient risks. The aim of this study was to develop two flexible parametric competing risk regression models (FPCRRMs) for local recurrence (LR) and distant metastasis (DM), aiming at providing guidance on how to individually follow-up patients. Three thousand sixteen patients (1931 test, 1085 validation cohort) with high-grade eSTS were included in this retrospective, multicenter study. Histology (9 categories), grading (time-varying covariate), gender, age, tumor size, margins, (neo)adjuvant radiotherapy (RTX), and neoadjuvant chemotherapy (CTX) were used in the FPCRRMs and performance tested with Harrell-C-index. Median follow-up was 50 months (interquartile range: 23.3–95 months). Two hundred forty-two (12.5%) and 603 (31.2%) of test cohort patients developed LR and DM. Factors significantly...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research