Cancers, Vol. 12, Pages 47: Individualizing Follow-Up Strategies in High-Grade Soft Tissue Sarcoma with Flexible Parametric Competing Risk Regression Models
Cancers, Vol. 12, Pages 47: Individualizing Follow-Up Strategies in High-Grade Soft Tissue Sarcoma with Flexible Parametric Competing Risk Regression Models
Cancers doi: 10.3390/cancers12010047
Authors:
Smolle
Sande
Callegaro
Wunder
Hayes
Leitner
Bergovec
Tunn
van Praag
Fiocco
Panotopoulos
Willegger
Windhager
Dijkstra
van Houdt
Riedl
Stotz
Gerger
Pichler
Stöger
Liegl-Atzwanger
Smolle
Andreou
Leithner
Gronchi
Haas
Szkandera
Currently, patients with extremity soft tissue sarcoma (eSTS) who have undergone curative resection are followed up by a heuristic approach, not covering individual patient risks. The aim of this study was to develop two flexible parametric competing risk regression models (FPCRRMs) for local recurrence (LR) and distant metastasis (DM), aiming at providing guidance on how to individually follow-up patients. Three thousand sixteen patients (1931 test, 1085 validation cohort) with high-grade eSTS were included in this retrospective, multicenter study. Histology (9 categories), grading (time-varying covariate), gender, age, tumor size, margins, (neo)adjuvant radiotherapy (RTX), and neoadjuvant chemotherapy (CTX) were used in the FPCRRMs and performance tested with Harrell-C-index. Median follow-up was 50 months (interquartile range: 23.3–95 months). Two hundred forty-two (12.5%) and 603 (31.2%) of test cohort patients developed LR and DM. Factors significantly...
Source: Cancers - Category: Cancer & Oncology Authors: Smolle Sande Callegaro Wunder Hayes Leitner Bergovec Tunn van Praag Fiocco Panotopoulos Willegger Windhager Dijkstra van Houdt Riedl Stotz Gerger Pichler St öger Liegl-Atzwanger Smolle Andreou Leithner Gronchi Haas Szkandera Tags: Article Source Type: research
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