Recommendations for the use of Japanese encephalitis vaccines

Japanese encephalitis (JE) is a mosquito-borne viral infection which is prevalent in Taiwan. The virus circulates in an enzootic cycle in pigs which serve as amplifying hosts. Outbreaks typically occur during summer. A universal vaccination program using 4-shot mouse brain-derived inactivated vaccine has successfully controlled JE epidemics in Taiwan since 1968. More than 90% of JE cases in recent years were older than 20 years in Taiwan. Because of several drawbacks, mouse brain-derived vaccine has been replaced by newer generation JE vaccines, including inactivated Vero cell-derived vaccine and live chimeric vaccine.

Source: Pediatrics and Neonatology - December 19, 2019 Category: Perinatology & Neonatology Authors: Ping-Ing Lee, Yhu-Chering Huang, Kao-Pin Hwang, Ching-Chuan Liu, Cheng-Hsun Chiu, Po-Yen Chen, Chun-Yi Lu, Chih-Jung Chen, Luan-Yin Chang, Nan-Chang Chiu, Hsin Chi, Hsiao-Chuan Lin, Keh-Gong Wu, Yu-Huai Ho, Wu Sun, Tzou-Yien Lin Tags: Review Article Source Type: research