Clarithromycin Plus Certain Statins Associated with Hospitalization Risk in Older Adults (FREE)

By Kelly Young Edited by David G. Fairchild, MD, MPH Clarithromycin — when coprescribed with some statins in older adults — is associated with increased risks for adverse outcomes including mortality, according to an observational study …
Source: Physician's First Watch current issue - Category: Primary Care Source Type: news

Related Links:

CONCLUSIONS: Simvastatin is effective in ameliorating TC and TG elevated by olanzapine. Modulation of BAT activity by statins could be a partial mechanism in reducing metabolic side effects caused by SGAs in child and adolescent patients. PMID: 32605639 [PubMed - in process]
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
Patients hospitalised with COVID-19 who take statins are less likely to die than those who do not, a retrospective study published in Cell Metabolism suggests.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Conclusions: This study defines a novel pathway of E2F1-miR-378a-3p-SORT1-ApoB100 that controls levels of circulating VLDL/LDL cholesterol and triglycerides by modulating degradation and secretion of ApoB100, and suggests the use of miR-378a-3p as a potential therapeutic target for dyslipidemia.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Conclusion: In conclusion, when an elevated blood pressure was discovered in elderly persons at a health screening, 70% of those received a hypertension diagnosis within 10 years, with a mean time to diagnosis of 5 years. Health care actions should be enforced to shorten this time lag both in terms of information to the individuals, as well as the handling of this patient group in primary care. PMID: 32603237 [PubMed - as supplied by publisher]
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Publication date: Available online 2 July 2020Source: Indian Heart JournalAuthor(s): Abhinav Grover, Mansi Oberoi
Source: Indian Heart Journal - Category: Cardiology Source Type: research
Authors: Tang B, Xiao S Abstract Objective: To analyze the risk factors for upper gastrointestinal bleeding (UGIB) in patients with ST-segment elevation myocardial infarction (STEMI) during double antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI). Methods: A total of 388 patients treated from January 2015 to September 2017 due to STEMI were selected. Thirty-two cases of UGIB occurring during DAPT after PCI were included as a UGIB group, and another 356 cases without UGIB were set as a control group. Age, gender, body mass index, smoking, drinking, history of previous diseases (hypertens...
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
Conclusion: Multiple strengths of glimepiride and metformin fixed dose combinations are beneficial in T2DM, irrespective of age, duration of diabetes, BMI, diabetes complications, use of concomitant medications such as insulin and statin. Glimepiride and metformin fixed dose combinations were not associated with a significant risk of hypoglycemia. PMID: 32602682 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Streptococcus pneumoniae is an opportunistic pathogen responsible for widespread illness and is a major global health issue for children, the elderly, and the immunocompromised population. Pneumolysin (PLY) is a cholesterol-dependent cytolysin (CDC) and key pneumococcal virulence factor involved in all phases of pneumococcal disease, including transmission, colonization, and infection. In this review we cover the biology and cytolytic function of PLY, its contribution to S. pneumoniae pathogenesis, and its known interactions and effects on the host with regard to tissue damage and immune response. Additionally, we review s...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion(s): There is a high risk of MACE after sepsis especially among those in statin indicated groups with significant clinical inertia in prescribing practices.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
Now that marijuana is legal for medical or recreational use in many states, growing numbers of Americans — including older people — are imbibing this popular drug. In fact, the percentage of people ages 65 and older who said they used some form of marijuana almost doubled between 2015 and 2018, a recent study reports. Compared with prescription drugs, the health consequences of using marijuana are not nearly as well studied. But converging evidence suggests that the drug may be harmful for the heart, according to a review article in JACC: Journal of the American College of Cardiology. More than two million Amer...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Heart Health Marijuana Source Type: blogs
More News: Biaxin | Cholesterol | Clarithromycin | Primary Care | Statin Therapy | Study