Acute and Chronic Efficacy of Bumetanide in an in vitro Model of Posttraumatic Epileptogenesis.

CONCLUSIONS: Our data demonstrate a persistent contribution of NKCC1 cotransport in posttraumatic ictal-like activity, presumably as a consequence of chronic alterations in neuronal chloride homeostasis and GABA-mediated inhibition. New strategies for more effective reduction in posttraumatic and seizure-induced [Cl(-) ]i accumulation could provide the basis for effective treatments for posttraumatic epileptogenesis and the resultant seizures. PMID: 25495911 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Tags: CNS Neurosci Ther Source Type: research