Low CSF CD4/CD8 + T-cell proportions are associated with blood–CSF barrier dysfunction in limbic encephalitis

ConclusionsThese findings suggest that the proportion of CD4 + and CD8 + T-cells in the CSF of patients with LE associated with blood–CSF barrier dysfunction plays a potential role in CNS (central nervous system) inflammation in these patients. Thus, flow cytometry as a methodology reveals novel insights into LE's genesis and symptomatology. The CD4/8 + T-cell ratio in PB as a biomarker for LE requires further investigation.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research