Smart device-based detection of atrial fibrillation: Opportunities and challenges in the emerging world of digital health

Atrial fibrillation (AF) is a growing epidemic in the aging world population [1]. In many patients AF can be asymptomatic leading to an underestimation of its true prevalence and incidence. Conceptually, AF is increasingly considered the consequence of an atrial cardiomyopathy that results from the combined effects of genetic predisposition, risk factors and co-morbidities [2]. Once AF occurs, it causes changes in the structure and function of the atria (atrial remodelling), which promote AF re-initiation and maintenance [3].
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research

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The objective of this study was to evaluate the long-term clinical outcomes and the incidence of permanent pacemaker implantation after catheter ablation in patients with of atrial fibrillation (AF) and sinus node dysfunction (SND). METHODS: Among 3,068 total consecutive patients who underwent AF catheter ablation (AFCA), this study included 222 (9.5%; men 53.2%, 63.7±9.2 years of age, 81.5% paroxysmal AF) with underlying SND and a regular rhythm follow-up. We analyzed the rhythm outcomes, changes in the mean heart rate or heart rate variability, and permanent pacemaker implantation rate. RESULTS: During 47....
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
Authors: Shin DG, Lim HE PMID: 31960634 [PubMed]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
This study investigated ICD-lead intracardiac parameters over a long duration in patients with ARVC and HCM and compared these parameters with those of a control group. We included 50 patients (mean age, 55.2 ± 17.2 years; 26% female) with ICD leads in the right ventricular apex, and compared 7 ARVC and 14 HCM patients with 29 control patients without structural heart disease. ICD-lead parameters, including R-wave amplitude, pacing threshold, and impedance during follow-up, were compared. The difference in these parameters between the time of implantation and year 5 were also compared. There were no significant diff...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Authors: Huang M, Zheng J, Chen Z, You C, Huang Q Abstract Coronary collateral circulation (CCC) plays a crucial role in myocardial blood supply, especially for ischemic myocardium. Previous study has shown that neuregulin-1 is a prominent angiogenic factor in diabetic cardiomyopathy, whereas the relationship between neuregulin-1 and CCC has not been investigated. Thus, we aimed to investigate relationship between circulating neuregulin-1 levels and CCC in stable coronary artery disease patients.Coronary artery disease patients with a stenosis of ≥ 90% as evidenced by coronary angiography were included in our st...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Authors: Wu CC, Chang CS, Hsu CC, Wang CP, Tsai IT, Lu YC, Houng JY, Chang CC, Chung FM, Lee YJ, Hung WC Abstract Low-circulating levels of adiponectin (ADPN) are associated with obesity, diabetes mellitus, and coronary artery disease. On the contrary, some studies have demonstrated a link between relatively high levels of plasma ADPN and heart failure, atrial fibrillation, and adverse outcome. However, little is known about the relationship between ADPN level and prolonged QT interval. The aim of this study was to investigate the association between plasma ADPN levels and prolonged QT interval in patients with sta...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Authors: Fujino T, Yuzawa H, Kinoshita T, Koike H, Shinohara M, Akitsu K, Yao S, Yano K, Suzuki T, Yamada M, Ikeda T Abstract Catheter ablation is currently an established treatment for symptomatic paroxysmal atrial fibrillation (AF). We focused on elderly patients with a high prevalence of AF and attempted to identify the clinical factors associated with unsuccessful ablation outcomes.Among 735 consecutive patients who underwent AF ablation procedures, 108 (14.7%, 66 men) aged ≥ 75 years were included. Of them, 80 had paroxysmal AF, and the remaining 28 non-paroxysmal AF. All patients underwent pulmonary vein (...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
san M Abstract Over the past three decades, the increasing rates of obesity have led to an alarming obesity epidemic worldwide. Obesity is associated with an increased risk of cardiovascular diseases; thus, it is essential to define the molecular mechanisms by which obesity affects heart function. Individuals with obesity and overweight have shown changes in cardiac structure and function, leading to cardiomyopathy, hypertrophy, atrial fibrillation, and arrhythmia. Autophagy is a highly conserved recycling mechanism that delivers proteins and damaged organelles to lysosomes for degradation. In the hearts of patien...
Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
AbstractPurpose of ReviewAtrial fibrillation (AF) and heart failure (HF) are cardiovascular disease epidemics with increasing prevalence worldwide. AF can either be a cause or consequence of cardiomyopathy and HF. Catheter ablation (CA) has been a proven therapy for symptomatic, medically refractory AF patients. The purpose of this review is to highlight the role as well as timing of CA in treating AF patients with HF.Recent FindingsMultiple randomized clinical trials in recent years have elegantly demonstrated the superiority of CA in improving survival, quality of life, ventricular function, and reduce hospitalizations, ...
Source: Current Cardiovascular Risk Reports - Category: Cardiology Source Type: research
Authors: Batul SA, Gopinathannair R Abstract Atrial fibrillation (AF) and heart failure (HF) are growing cardiovascular disease epidemics worldwide. There has been an exponential increase in the prevalence of AF and HF correlating with an increased burden of cardiac risk factors and improved survival rates in patients with structural heart disease. AF is associated with adverse prognostic outcomes in HF and is most evident in mild-to-moderate left ventricular (LV) dysfunction where the loss of "atrial kick" translates into poorer quality of life and increased mortality. In the absence of underlying struct...
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
This open access paper takes a brief tour of the dominant themes in the aging of heart tissue, viewed structurally and biochemically. These are some of the changes that have yet to be assembled into a coherent and generally agreed upon chain of events, starting with fundamental cellular damage, and proceeding through successive layers of cause and consequence in reaction to that damage. Most of the research community begins a line of inquiry with an investigation of one facet of the aged, diseased state. Researchers then attempt to work backwards to identify and address proximate causes of the observed problems, one by one...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
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