A Study to Evaluate the Efficacy and Safety of Bismuth-Containing Quadruple Therapy With Oral Vonoprazan (TAK-438) 20 mg Compared to Esomeprazole 20 mg Twice Daily in Paticipants With Helicobacter Pylori Infection

Condition:   Helicobacter Pylori Interventions:   Drug: Vonoprazan;   Drug: Amoxicillin;   Drug: Clarithromycin;   Drug: Bismuth Potassium citrate;   Drug: Esomeprazole Sponsor:   Takeda Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Publication date: Available online 25 January 2020Source: Current Opinion in Food ScienceAuthor(s): Oluwadara Oluwaseun Alegbeleye, Anderson S Sant’AnaEmerging pathogens, which although have been periodically detected in produce items, are comparatively rarely implicated in large outbreaks. Many of these pathogens are inhabitants of the natural environment and may be major potential sources of contamination for fruits and vegetables. This overview examines the growing epidemiological relevance of three of such emerging pathogens; Arcobacter spp., Helicobacter pylori and Cronobacter sakazakii and the recent status of ...
Source: Current Opinion in Food Science - Category: Food Science Source Type: research
Source: Gut Microbes - Category: Microbiology Authors: Source Type: research
Source: Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Condition:   Helicobacter Pylori Infection Intervention:   Diagnostic Test: stomach biopsies Sponsor:   Hospital Universitario Dr. Jose E. Gonzalez Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: The seroprevalence ofH. pylori antibodies was lower compared to most developing countries. Keeping a dog, household size, indoor tap water, fathers ’ occupation and diabetes mellitus type 1 were found to be independent predictors of presence ofH. pylori antibodies.Keywords:Helicobacter Pylori.
Source: African Health Sciences - Category: African Health Source Type: research
AbstractBackgroundHelicobacter pylori infection and hyperplastic polyp are known to have strong connections, but there are not enough randomized controlled trial data.AimsTo evaluate the effect ofH. pylori eradication on gastric hyperplastic polyp.MethodThis is an open-labeled, single-center, randomized controlled trial. Patients with hyperplastic polyp and current infection ofH. pylori were randomly assigned to eradication or non-eradication groups. All participants underwent follow-up endoscopy to investigate the regression of gastric polyps. Gastric polyp regression was defined as the disappearance of polyps or a reduct...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Source: Clinical and Experimental Gastroenterology - Category: Gastroenterology Tags: Clinical and Experimental Gastroenterology Source Type: research
Conclusions This review summarizes current progress made in endoscopic diagnosis of H. pylori infection. At present there is no single diagnostic approach that provides validated diagnostic accuracy. Further prospective studies are required, as is development of a validated classification system. Early studies in computer-aided diagnosis suggest potential for a high level of accuracy but real-time results are awaited. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Review Source Type: research
Conclusions: Gastric cancer has the fourth highest incidence of various cancers worldwide and is ranked second as a cause of cancer-related death. It exists from the antiquity and a lot of hypotheses have been developed about its etiology during the centuries, influencing its therapy. During the 20th century, thanks to the scientific and technological progresses the causes of the cancer have been discovered and the role of the bacterium Helicobacter pylori has been demonstrated, and new perspective research are currently trying to investigate the role of other microorganisms in gastric physiopathology, as well as its possi...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
In this study, we analyzed the bacterial energetic requirements associated with these cellular alterations. Mutant strains lacking Cagα, Cagβ, or CagE (putative ATPases corresponding to VirB11, VirD4, and VirB4 in prototypical T4SSs) were capable of T4SS core complex assembly but defective in CagA translocation into host cells. Thus, the three Cag ATPases are not functionally redundant. Cagα and CagE were required for H. pylori-induced NF-B activation, IL-8 secretion, and TLR9 activation, but Cagβ was dispensable for these responses. We identified putative ATP-binding motifs (Walker-A and Walker-B) in...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Molecular Pathogenesis Source Type: research
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