Are Linear Measurements of the Nucleus Basalis of Meynert Suitable as a Diagnostic Biomarker in Mild Cognitive Impairment and Alzheimer Disease? [ADULT BRAIN]

CONCLUSIONS: There is progressive NBM thinning across the aging-dementia spectrum, which correlates with cognitive decline and CSF markers of amyloid-β pathology. We show high diagnostic accuracy but limited reliability, representing an area for future improvement. NBM thickness is a promising, readily available MR imaging biomarker of Alzheimer disease warranting diagnostic-accuracy testing in clinical practice.

http://www.ajnr.org/cgi/content/abstract/40/12/2039?rss=1

Source: American Journal of Neuroradiology - December 12, 2019 Category: Radiology Authors: Jethwa, K. D., Dhillon, P., Meng, D., Auer, D. P., for the Alzheimers Disease Neuroimaging Initiative Tags: ADULT BRAIN Source Type: research