PD-L1 Inhibitor-Induced Thyroiditis is Associated with Better Overall Survival in Cancer Patients.

CONCLUSIONS: PD-L1 inhibitors lead to immune mediated thyroiditis, the most frequent endocrine IRAE. In most cases, management is supportive without requiring steroids or discontinuation of immunotherapy. Diffusely increased thyroid ¹⁸FDG uptake on PET scan may predict the occurrence of thyroiditis, whereas TPO antibodies may help identify its severity. Thyroiditis may be a biomarker for anti-tumor immune response, highlighting the need to further characterize its underlying mechanism.
PMID: 31813343 [PubMed - as supplied by publisher]

Source: Thyroid : official journal of the American Thyroid Association - December 10, 2019 Category: Endocrinology Tags: Thyroid Source Type: research