Cardiac safety assessment with motion field imaging analysis of human iPS cell-derived cardiomyocytes is improved by an integrated evaluation with cardiac ion channel profiling.

In conclusion, the MFI assay with hiPS-CMs would be useful for evaluating multiple cardiac liabilities. The ion channel profile helps to interpret the results of MFI assay and correctly evaluate cardiac risks. Therefore, an integrated cardiac safety assessment with MFI and ion channel profiling is recommended. PMID: 31813905 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31813905?dopt=Abstract

Source: Journal of Toxicological Sciences - December 10, 2019 Category: Toxicology Tags: J Toxicol Sci Source Type: research