Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data?

This article highlights how the opioid system potently modulates mesolimbic circuitry underlying motivation and reward processing, limbic circuitry underlying fear and anxiety responses, cortical and hippocampal circuitry underlying a variety of cognitive functions, as well as broad functional and structural plasticity mechanisms. Ultimately, a more thorough understanding of how the opioid system modulates these core functional domains may lead to novel treatment strategies and molecular targets in the treatment of MDD.
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research

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Publication date: Available online 22 January 2020Source: Journal of Contextual Behavioral ScienceAuthor(s): Shuanghu Fang, Dongyan DingAbstractCompared to the use of Acceptance and Commitment Therapy (ACT) in the treatment of adult psychopathology, there are fewer empirical studies on children, which makes it difficult to summarize the use of ACT in children. The current study presented the results of a meta-analysis of 14 randomized controlled trials (RCTs) on the efficacy of ACT for 1189 children. Compared with treatment as usual (TAU) and waitlist, ACT significantly improved the symptoms of primary outcome measures suc...
Source: Journal of Contextual Behavioral Science - Category: Psychiatry & Psychology Source Type: research
ConclusionThese data offer preliminary evidence that an adjunct EAAT program is acceptable for veterans with PTSD and/or TBI participating in an IOP.
Source: Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Authors: Manske A, Schmidt SJ Abstract Mediators of Problematic Social Media Use in Adolescence as Possible Mechanisms of Change in Psychotherapy Social media are omnipresent in the lives of adolescents. Problematic use of social media has been linked to adverse mental health outcomes including depression, anxiety, suicidality, self-harm, body dissatisfaction and eating pathology. Preliminary evidence suggests that interventions aiming at reducing the amount of time spent in social media and changing dysfunctional beliefs about social media use are promising. However, the mechanisms of change of these interventions...
Source: Praxis der Kinderpsychologie und Kinderpsychiatrie - Category: Child Development Tags: Prax Kinderpsychol Kinderpsychiatr Source Type: research
CONCLUSIONS: This study demonstrates the potential of the Mood Outcomes Program to create a nationwide "learning health system" for mood disorders. This goal will be further realized as the program expands in reach and scope across additional NNDC sites. PMID: 31960777 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
CONCLUSIONS: Technology has great potential for increasing availability of training opportunities for clinicians and increasing the workforce trained in EBTs. Although technology-assisted training programs are not without limitations, overall they promise a new era of facilitative learning that promotes the adoption of new clinical practices in a dynamic and efficient manner. PMID: 31960775 [PubMed - as supplied by publisher]
Source: Psychiatric Services - Category: Psychiatry Tags: Psychiatr Serv Source Type: research
ConclusionsThe current study supports the growing body of literature suggesting that using social networking sites to alleviate boredom and socially connect, may place individuals at increased risk for developing pathological tendencies and patterns of behavior towards social networking sites.
Source: Journal of Adolescence - Category: Child Development Source Type: research
This article reviews randomized controlled trials and non-randomized studies to better understand the effectiveness of psychological interventions for anxiety and depression during pregnancy in Latinas and Black women. Additionally, this review summarizes important characteristics of interventions such as intervention format, treatment modality, and the use of cultural adaptations. Literature searches of relevant research citation databases produced 68 studies, 13 of which were included in the final review. Most studies were excluded because their samples were not majority Latina or Black women, or because they did not tes...
Source: Clinical Psychology and Psychotherapy - Category: Psychiatry Tags: Clin Psychol Psychother Source Type: research
Comorbidity is the presence of one or more additional conditions co-occurring with a primary condition. In this episode, host schizophrenic Rachel Star Withers with her cohost Gabe Howard will be discussing comorbidity with schizophrenia. Comorbidity is associated with worse health outcomes, more complex clinical management and increased health care costs. Occupational therapist and host of the podcast Occupied, Brock Cook, will be joining us to discuss ways that he works with people with schizophrenia to manage multiple health issues.  Highlights from “Comorbidity with Schizophrenia” Episode [01:28] What ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antipsychotic Inside Schizophrenia Mental Health and Wellness Psychiatry Psychology Psychotherapy Bipolar disorder and schizophrenia comorbid comorbid psychiatric conditions Comorbidities Comorbidity Diagnosis Of Schizophrenia Livi Source Type: blogs
This study aimed to investigate the effect of Holy Quran on stress, anxiety and depression in Iranian pregnant women. A total of 168 participants were allocated randomly into three groups. Group I received broadcast of the Holy Quran with translation, group II received broadcast of the Holy Quran without translation, and group III was the control group. After intervention, scores of perceived stress, state anxiety, trait anxiety and depression in group I and group II were significantly lower compared with the control group. The Holly Quran with translation and without it, both are the effective for reducing stress, anxiety...
Source: Journal of Religion and Health - Category: Medical Ethics Source Type: research
This article discusses the development and initial validation of the Dual Self-Directed Humor Scale (DSDHS), the first instrument to evaluate individual differences in the two dimensions of self-directed humor (SDH). The DSDHS assumes two distinct dimensions: Deleterious SDH and Benign SDH. While the former is potentially harmful to well-being, the latter is potentially beneficial. By employing 400 participants in Study 1, the validity of the two-factor model of the DSDHS was demonstrated. In Study 2, which included 446 participants, evidence for concurrent validity was shown by correlating the DSDHS with other humor measu...
Source: Personality and Individual Differences - Category: Psychiatry & Psychology Source Type: research
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