Gene expression signature induced by grape intake in healthy subjects reveals wide-spread beneficial effects on peripheral blood mononuclear cells

Publication date: Available online 9 December 2019Source: Journal of Functional FoodsAuthor(s): Rosa Anna Milella, Marica Gasparro, Fiammetta Alagna, Maria Francesca Cardone, Silvia Rotunno, Concetta Tiziana Ammollo, Fabrizio Semeraro, Apollonia Tullo, Flaviana Marzano, Domenico Catalano, Donato Antonacci, Mario Colucci, Domenica D'EliaAbstractUsing a transcriptomic approach, we performed a pilot study in healthy subjects to evaluate the changes in gene expression induced by grape consumption. Blood from twenty subjects was collected at baseline (T0), after 21 days of grape-rich diet (T1) and after one-month washout (T2). Gene expression profiling of peripheral blood mononuclear cells from six subjects identified 930 differentially expressed transcripts. Gene functional analysis revealed changes (at T1 and/or T2) suggestive of antithrombotic and anti-inflammatory effects, confirming and extending previous finding on the same subjects. Moreover, we observed several other favourable changes in the transcription of genes involved in crucial processes such as immune response, DNA and protein repair, autophagy and mitochondrial biogenesis. Finally, we detected significant changes in many long non-coding RNAs genes, whose regulatory functions are being increasingly appreciated. Altogether, our data suggest that a grape diet may exert its beneficial effects by targeting different strategic pathways.Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research

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Publication date: Available online 25 January 2020Source: Anaesthesia &Intensive Care MedicineAuthor(s): Geoff FrawleyAbstractAdvances in neonatal medicine have progressively increased the survival of premature infants. Increased survival has, however, come at the cost of increased number of infants with prematurity related complications. This is represented by high rates of respiratory distress syndrome, bronchopulmonary dysplasia, necrotising enterocolitis, sepsis, periventricular leukomalacia, intraventricular haemorrhage, cerebral palsy, hypoxic ischaemic encephalopathy and visual and hearing problems in survivors....
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Publication date: Available online 25 January 2020Source: Anaesthesia &Intensive Care MedicineAuthor(s): Graham Knottenbelt, Amanda DaltonAbstractSpecialist surgery in infancy provides challenges for paediatric anaesthetists. There is growing appreciation that the relatively higher rate of severe critical events in infants during the perioperative period requires appropriate competence, experience and resources for the safe conduct of anaesthesia. Both common (inguinal hernias and hypertrophic pyloric stenosis) and less common conditions (tracheo-oesophageal fistula, congenital diaphragmatic hernia, exomphalos, gastros...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Conclusion: In conclusion, RIOS considerably contributes to radiation induced adaptive responses. Other possible molecular adaptors modulating RIOS-induced responses are yet to be divulged in future studies. PMID: 31976798 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Publication date: Available online 25 January 2020Source: The Annals of Thoracic SurgeryAuthor(s): Eilon Ram, Ehud Schwammenthal, Hillit Cohen, Alexander Kogan, Yael Peled, Leonid Sternik, Ehud RaananiAbstractBackgroundDegenerative mitral valve disease involving anterior leaflet pathology is considered less favorable regarding durability of surgical repair than isolated posterior leaflet disease. We aimed to compare the outcomes of patients undergoing mitral valve repair for anterior, posterior and bileaflet pathologies, and to investigate predictors for repair failure.MethodsOf the 760 consecutive patients with degenerati...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ConclusionsThis multicenter clinical trial describes excellent 5-year outcomes and durable exclusion of blunt thoracic aortic injury using a novel stent graft system. TEVAR with this endograft appears to be a safe and effective treatment option for patients with BTAI.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 25 January 2020Source: The Annals of Thoracic SurgeryAuthor(s): Driss Raissi, Qian Yu, Victor A. Ferraris, Michael WinklerAbstractEndobronchial stenting is a well-established palliative approach in lung cancer patients with airway obstruction secondary to tumor burden. However, endobronchial stenting can be complicated by stent erosion into adjacent vessels. While most cases of endobronchial stent related hemoptysis can be treated by stent revision and/or surgical resection, here, we present a case managed by endovascular pulmonary arterial stent placement as a last resort option in the m...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 23 January 2020Source: Sensors and Actuators B: ChemicalAuthor(s): Lorena Biondi, Marcus Perry, Jack McAlorum, Christos Vlachakis, Andrea HamiltonAbstractMoisture plays a critical role in reinforced concrete corrosion, underpinning structural degradation which costs the global economy a staggering $350 bn per year (0.5% GDP). Both moisture sensors and repair materials that limit water ingress are required, but monitoring and maintenance are often viewed as separate challenges. This paper outlines a first-time demonstration of moisture sensors based on low calcium fly ash geopolymers ...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Authors: Yeung M, Shin JJ, Lesniak BP, Lin A Abstract INTRODUCTION: The purpose of this study was to compare complication rates between arthroscopic versus open biceps tenodesis in the setting of arthroscopic rotator cuff repair and to determine the effect of fellowship training on complication rates. METHODS: The American Board of Orthopaedic Surgery database was used to identify cases of arthroscopic and open biceps tenodesis in the setting of rotator cuff repair between 2012 and 2016. Surgical, medical, and anesthetic complications, location, fellowship training, surgery year, and patient demographic data we...
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
CONCLUSION: A well-designed database and user-friendly interface have greater potential for research utility, clinical efficiency, and, thus, cost-effectiveness when compared with standard voice-dictated operative notes. Widespread utilization of such tools can accelerate the pace and improve the quality of orthopaedic clinical research. LEVEL OF EVIDENCE: Level IV. PMID: 31977610 [PubMed - in process]
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
Publication date: Available online 25 January 2020Source: The American Journal of SurgeryAuthor(s): Sharven Taghavi, Glenn Jones, Juan Duchesne, Patrick McGrew, Chrissy Guidry, Rebecca Schroll, Charles Harris, Reginald Nkansah, Tomas Jacome, Danielle TatumAbstractBackgroundThe association of procedure volume and improved outcomes has been established with infrequently performed elective operations. However, effect of trauma center volume on outcomes in emergency surgery has not been defined. We hypothesized that high volume centers (HVC) would provide better outcomes for operative major vascular injuries (MVI) than low vol...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
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