Safety and efficacy of magnetic resonance imaging-guided focused ultrasound neurosurgery for Parkinson ’s disease: a systematic review

This study aimed to investigate the safety and efficacy of MRgFUS for PD by systematically reviewing related literature. PubMed and EMBASE were searched to identify related studies. Inclusion criteria were (1) reported the efficacy or sa fety of MRgFUS for PD and (2) published in English. Exclusion criteria were (1) nonhuman study, (2) review or meta-analysis or other literature types without original data, and (3) conference abstract without full text. Data on study characteristics, treatment parameters, efficacy, and adverse event s were collected. Descriptive synthesis of data was performed. Eleven studies containing 80 patients were included. Nine studies were observational studies with no controls. Two studies included a randomized and controlled phase. Most studies included tremor-dominant PD. Ten studies reported decline of UPDRS-III scores after MRgFUS, and five reported a statistically significant decline. Nine studies evaluated the quality of life (QOL). Significant improvement of QOL was reported by four studies using the 39-item Parkinson’s disease questionnaire. Four studies investigated the impact of MRgFU S on non-motor symptoms. Most tests indicated that MRgFUS had no significant effect on neuropsychological outcomes. Most adverse events were mild and transient. MRgFUS is a potential treatment for PD with satisfying efficacy and safety. Studies in this field are still limited. More studies with stri ct design, larger sample size, and longer follow-up are...
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research

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Conclusion: Anti-CV2 autoimmune encephalitis can present as Parkinsonism with bilateral leukoencephalopathy on MRI. PET scanning can be useful to reveal an occult cancer. Treatment of the cancer may improve the paraneoplastic neurological syndrome without the need of immunosuppressive therapy.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Authors: Lee EJ, Fomenko A, Lozano AM Abstract Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging new technology with considerable potential to treat various neurological diseases. With refinement of ultrasound transducer technology and integration with magnetic resonance imaging guidance, transcranial sonication of precise cerebral targets has become a therapeutic option. Intensity is a key determinant of ultrasound effects. High-intensity focused ultrasound can produce targeted lesions via thermal ablation of tissue. MRgFUS-mediated stereotactic ablation is non-invasive, incision-free, and confe...
Source: Journal of Korean Neurosurgical Society - Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research
In this study, we sought to assess the efficacy of botulinum toxin injections in Parkinson's disease-associated Pisa syndrome using a Magnetic Resonance Imaging-, Ultrasonography-, and Electromyography-guided combined approach.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Short communication Source Type: research
Authors: Sinai A, Katz Y, Zaaroor M, Sandler O, Schlesinger I Abstract Ablative incisionless neurosurgery has become possible through advances in focused ultrasound and magnetic resonance imaging (MRI). The great advantage of MRI-guided focused ultrasound (MRgFUS) is that the ablation is performed through an intact skull without surgery. Here, we review the new modality of MRgFUS for treating tremor and enlighten the role of the anesthesiologist in the unique procedural setting of the MRI suite. During the MRgFUS process, the patients should be awake and are required to cooperate with the medical staff to allow ass...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Insightec said this week it submitted an application for pre-market approval to the Japanese Pharmaceuticals and Medical Devices Agency seeking an indication for its Exablate Neuro to treat advanced Parkinson’s Disease in patients suffering from mobility, rigidity or dyskinesia. The Israel-based company’s Exablate Neuro device uses high-intensity, focused ultrasound to thermally ablate targeted tissue, guided by continuous magnetic resonance imaging; the procedure can be performed non-invasively through an intact skull. “Insightec is committed to supporting research that extends the applica...
Source: Mass Device - Category: Medical Devices Authors: Tags: Neurological Regulatory/Compliance Ultrasound INSIGHTEC Source Type: news
Movement Disorders, EarlyView.
Source: Movement Disorders - Category: Neurology Source Type: research
Insightec said today it closed a $150 million Series E private equity round of financing with plans to use funds to support marketing, commercialization and further development of its Exablate Neuro platform. The round was led by Koch Disruptive Technologies subsidiary Koch Industries, who invested a total of $100 million during the round, the Israel-based company said. The company’s flagship Exablate Neuro device, which won FDA approval last July for treating essential tremor, uses high-intensity, focused ultrasound to thermally ablate targeted tissue, guided by continuous magnetic resonance imaging; the proced...
Source: Mass Device - Category: Medical Devices Authors: Tags: Business/Financial News Wall Street Beat INSIGHTEC Source Type: news
Authors: Ito H, Fukutake S, Yamamoto K, Yamaguchi T, Taira T, Kamei T Abstract Thalamotomy is effective in treating refractory tremor in Parkinson's disease (PD). We herein report a PD patient who underwent left ventral intermediate nucleus and ventro oralis posterior nucleus thalamotomy using magnetic resonance imaging-guided focused ultrasound (MRgFUS). Right-side resting tremor and rigidity were abolished immediately following the ultrasound energy delivery. In addition, left-side resting tremor and rigidity also improved. No adverse events occurred during the procedure. We observed the exacerbation of bradykine...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Insightec said yesterday it raised $150 million in a Series E round of financing led by Koch Industries’ Koch Disruptive Technologies to support its MRI-guided focused ultrasound technologies. The round was led by Koch Disruptive Technologies and joined by existing investors Elbit Imaging, York Capital, Focus Holdings, GE Healthcare (NYSE:GE), GEOC and Meditech Advisors, the Israel-based company said. “This investment aligns well with the founding principles of both Koch Disruptive Technologies and Koch Industries. With a track record of driving innovation and improving patient outcomes, Insightec has...
Source: Mass Device - Category: Medical Devices Authors: Tags: Business/Financial News INSIGHTEC Source Type: news
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Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: Article Source Type: research
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