Recommendations to improve lipid control. Consensus document of the Spanish Society of Cardiology

Publication date: Available online 7 December 2019Source: Revista Española de Cardiología (English Edition)Author(s): Carlos Escobar, Manuel Anguita, Vicente Arrarte, Vivencio Barrios, Ángel Cequier, Juan Cosín-Sales, Isabel Egocheaga, Esteban López de Sa, Luis Masana, Vicente Pallarés, Leopoldo Pérez de Isla, Xavier Pintó, José Ramón González Juanatey, José Luis ZamoranoAbstractThe current control of low-density lipoprotein cholesterol among patients with atherosclerotic cardiovascular disease is very low and this is associated with an increase of cardiovascular outcomes. In addition, the latter this happens, the risk will be greater. This is mainly due to an insufficient use of the lipid-lowering therapy currently available. In fact, with current treatments (statins, ezetimibe and PCSK9 inhibitors), the majority of patients in secondary prevention should achieve low-density lipoprotein cholesterol goals. For these reasons, in this manuscript promoted by the Spanish Society of Cardiology we propose three simple and feasible decision-making algorithms that include the majority of clinical scenarios among patients with ischemic heart disease, with the double aim of attaining therapeutic goals in the majority of patients as soon as possible; in secondary prevention the magnitude of the benefit is risk- and time-dependent.ResumenEl control actual de la concentración de colesterol unido a l...
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research

Related Links:

Mass trial of drug inclisiran comes after health service strikes deal with NovartisThe NHS is to launch a mass trial of an as-yet unapproved twice-yearly cholesterol-lowering injection, which it hopes will save lives and cut medical bills for thousands of people who do not take statins.About 40,000 people with high “bad” or low-density lipoprotein cholesterol will be invited to join the trial of inclisiran by NHS England via their GPs. The NHS has struck a novel deal with drugmaker Novartis, which will provide the injections free in exchange for the results of the five-year trial, which will be run by the NHS s...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Heart disease NHS Society Health Statins Drugs Science Novartis UK news Pharmaceuticals industry Source Type: news
CONCLUSIONS: Considering the formation of saturated fatty acids, statin performed better in males. With Omega-3 polyunsaturated fatty acids involved, changes in lipoproteins, cholesterol and fatty acids (liver and myocardium) were similar to those caused by small doses of a statin drug. Effects from the combination of bisoprolol and acetylsalicylic acid were completely different from those caused by the use of statin. PMID: 31916523 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research
Title: AHA News: Statins May Do Double Duty on Heart Disease and CancerCategory: Health NewsCreated: 1/6/2020 12:00:00 AMLast Editorial Review: 1/7/2020 12:00:00 AM
Source: MedicineNet Cholesterol General - Category: Cardiology Source Type: news
In conclusion, CETP inhibition does not appear to affect size-specific LDL cholesterol but is likely to lower CHD risk by lowering concentrations of other atherogenic, apolipoprotein B-containing lipoproteins (such as remnant and VLDLs). Inhibition of CETP also lowers triglyceride composit ion in HDL particles, a phenomenon reflecting combined effects of circulating HDL, triglycerides, and apolipoprotein B-containing particles and is associated with a lower CHD risk in observational analyses. Our results reveal that conventional composite lipid assays may mask heterogeneous effects of emerging lipid-altering therapies.
Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research
  The original Wheat Belly book rocked the nutritional world with its revolutionary ideas. But, as time has passed, I’ve added new strategies and concepts that have expanded the overall program and taken the health, weight, and youth-preserving benefits even further. I have therefore collected all this new material into a new Revised &Expanded Edition. The new Revised &Expanded Edition of Wheat Belly is now available at all major bookstores. Here is a brief excerpt from the new foreword: Wheat Belly began as my modest effort to help people with heart disease stop relying on the revolving door of angiopla...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open autoimmune blood sugar bowel flora cholesterol diabetes Dr. Davis Gliadin gluten-free grain-free grains Inflammation low-carb microbiota prebiotic probiotic wheat belly Source Type: blogs
Prevalence set to soar by 40% among older people in eight major country markets, including the UK, forecast suggests Related items fromOnMedica Coronary heart disease remains UK ’s biggest killer Women less likely than men to achieve CHD targets Type 2 diabetes in 10 times more young people than realised NICE says far more people should take statins Apply different obesity criteria to BME patients
Source: OnMedica Latest News - Category: UK Health Source Type: news
Authors: Mühleck F, Laufs U Abstract Coronary artery disease (CAD) is the most frequent cause of morbidity and mortality worldwide. Lifestyle modifications and drug treatment of cardiovascular risk factors are able to effectively prevent CAD. The basis of prevention is the assessment of the individual cardiovascular risk, e.g. by using a validated risk score. Documented evidence for prevention of CAD is available for the control of hypertension using angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARB) and calcium antagonists, for the treatment of hypercholesterolemia using ...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
Abstract Ischemic heart disease (IHD), a severe condition of myocardium facing impediment in the supply of basic needs for cellular metabolism is caused by atherosclerosis. Though statin drugs could control the use of surgery on IHD patients, the complete rehabilitation or prophylaxis can be achieved through herbal-based medicines viz. either in the form of crude extract or pure phytocompounds. In the present study, pretreatment with leaf extract of Nelumbo nucifera Gaertn. was investigated for cardioprotective activity-in vitro by mitigating H2O2-induced oxidative stress. Analysis such as estimation of antioxidan...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
This study suggests that for most, managing CAD with medications alone (the conservative approach) is as safe and effective as the more invasive strategy of cardiac catheterization and opening of the blocked artery. Findings of the ISCHEMIA trial ISCHEMIA followed over 5,000 patients with significant narrowing in one or more coronary arteries. Half of the patients were randomly selected to receive conservative treatment with optimal medical therapy (OMT) and lifestyle changes to treat risk factors such as high blood pressure and high cholesterol. The other half were given OMT and also sent for cardiac catheterization (thre...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Source Type: blogs
Researchers are using artificial intelligence to measure a common marker of heart disease via lung cancer screenings. The research was presented at the annual meeting of the Radiological Society of North America (RSNA). Low-dose chest CT is approved for lung cancer screening in high-risk people, such as long-time smokers. While these CT scans are intended to diagnose lung cancer, coronary artery calcium, a measure of plaque in the arteries, is also visible on CT. The coronary artery calcium score derived from CT is a well-established measure that helps doctors decide who should get cholesterol-lowering preventive medicatio...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health IVD Source Type: news
More News: Cardiology | Cardiovascular | Cholesterol | Heart | Heart Disease | Spain Health | Statin Therapy | Vytorin | Zetia