Updates on the Genomics of Bladder Cancer and Novel Molecular Taxonomy

Urothelial carcinoma (UC) is the most common malignant neoplasm of the bladder that encompasses a wide spectrum of histopathologic features and various molecular alterations and subtypes, responsible for its significant morphologic and genomic heterogeneity. Morphologically, in addition to classic UC (not otherwise specified), many well documented variant histologies are a common finding in invasive UC, and include squamous, glandular, micropapillary, sarcomatoid, small cell/neuroendocrine, clear cell, lymphoepithelioma-like, and plasmacytoid types, among others. This review provides an update on the recent advances in the molecular characterization and novel molecular taxonomy of UC and variant histologies.
Source: Advances in Anatomic Pathology - Category: Pathology Tags: Review Articles Source Type: research

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Conditions:   Bladder Adenocarcinoma;   Bladder Mixed Adenocarcinoma;   Bladder Squamous Cell Carcinoma;   Bladder Urothelial Carcinoma;   Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant;   Infiltrating Bladder Urothelial Carcinoma With Giant Cells;   Infiltrating Bladder Urothelia l Carcinoma With Glandular Differentiation;   Infiltrating Bladder Urothelial Carcinoma With Trophoblastic Differentiation;   Infiltrating Bladder Urothelial Carcinoma, Clear Cell Variant;   Infiltrating Bladder Urothelial Carcinoma, Micropapi...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract Micropapillary carcinoma of the bladder (MPBC) is a variant type of infiltrating urothelial carcinoma, which portends a poor biological behavior in terms of disease stage at first diagnosis and clinical outcome; its peculiar morphology raises issues concerning the ability of tumor detection by imaging techniques and proper biopsy procedure, and the appropriate treatment for non-muscle infiltrating and muscle-infiltrating MPBC remains a matter of debate. On the basis of its established prognostic and therapeutic role in breast and gastro-esophageal cancer in the first instance, the human epidermal growth f...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Mol Clin Oncol Source Type: research
ConclusionsWhile MP UBC is associated with clinicopathological features of advanced disease, it is not associated with worse survival outcomes in patients undergoing RC. NAC results in pathological downstaging in a significant number of patients. Nevertheless, this does not translate into better survival outcomes. The optimal treatment of patients with cT1 remains controversial.Patient summaryOur results suggest that micropapillary urothelial bladder cancer does not necessarily mandate different treatment algorithms. Nevertheless, each case should be discussed individually considering other clinicopathological factors.
Source: European Urology - Category: Urology & Nephrology Source Type: research
Conditions:   Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant;   Infiltrating Bladder Urothelial Carcinoma With Glandular Differentiation;   Infiltrating Bladder Urothelial Carcinoma With Squamous Differentiation;   Infiltrating Bladder Urothelial Carcinoma, Micropapillary Variant;   Infiltr ating Bladder Urothelial Carcinoma, Plasmacytoid Variant;   Metastatic Urothelial Carcinoma;   MTAP Negative Interventions:   Drug: Avelumab;   Drug: Pemetrexed Sponsors:   M.D. Anderson Cancer Center;   National Cancer&nbs...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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