Takotsubo cardiomyopathy caused by infusion reaction to trastuzumab
AbstractTakotsubo cardiomyopathy (TCM) is also known as stress-induced cardiomyopathy. The occurrence of TCM due to infusion reaction is extremely rare. A 65-year-old man began receiving trastuzumab monotherapy for gastric cancer. However, he developed an infusion reaction after administration. Electrocardiography revealed negative T waves, ST segment elevation, and apical akinesis and hypokinesis of the left ventricle with apical ballooning in the systole and diastole. Furthermore, troponin I and creatinine kinase (CK) levels and CK-myocardial band were elevated. Based on these findings, he was diagnosed with TCM. This is the first report of TCM due to an infusion reaction.
ConclusionHigh levels of lifestyle-related cancer-risk behaviors were found in most of the Hong Kong construction workers studied. The present study contributes to understanding how cancer-related lifestyle risk behaviors cluster among construction workers and relative impact factors of risk behaviors. It is essential to tailor health behavior interventions focused on multiple risk behaviors among different groups for further enlarging the effects on cancer prevention.
We report one case, in which the patient presented to the emergency department with lower urinary tract symptoms, fever and consumptive syndrome. Acute prostatitis was initially suspected, but subsequently prostate adenocarcinoma was diagnosed.This case enables us to consider the possibility of prostate adenocarcinoma as the diagnose in patients with fever of unknown origin, and the role of procalcitonin to rule out the presence of infection.
Publication date: Available online 21 January 2020Source: European UrologyAuthor(s): Charalampos Fragkoulis, Georgios Papadopoulos, Konstantinos Ntoumas
Publication date: Available online 21 January 2020Source: European UrologyAuthor(s): Jae Heon Kim, In Gab Jeong
Publication date: Available online 21 January 2020Source: European UrologyAuthor(s): Chang Wook Jeong, Samuel L. Washington, Annika Herlemann, Scarlett L. Gomez, Peter R. Carroll, Matthew R. CooperbergAbstractBackgroundActive surveillance (AS)/watchful waiting (WW) strategy for localized prostate cancer (PCa) is increasingly and broadly endorsed as a preferred option for initial treatment of men with very low- and low-risk PCa, but outcomes can be difficult to analyze in traditional, population-based registries. The recently released Surveillance, Epidemiology, and End Results (SEER) Prostate with WW dataset provides an op...
ConclusionsElderly patients had the same management as young patients, with no difference in surgery or survival, but with an increase in early loss of autonomy.
Publication date: Available online 22 January 2020Source: European Journal of Surgical OncologyAuthor(s): Isacco Montroni, Nicole M. Saur
ConclusionIn this experimental model, combined therapy with chemotherapy and Adv-shPGK1 improves control of PM of gastric origin as compared to chemotherapy alone and might counteract chemoresistance of PM. A systemic toxicity of Adv-shPGK1 cannot be excluded.
We read with interest your letter to the editor expressing concern about using ROCK2 inhibition for diabetic cardiomyopathy (DCM) management, as it may promote tumor metastasis and disturb some physiological functions. However, the effect of ROCK2 on metastasis seems to be tumor and context specific. In fact, numerous studies reported a metastasis-promoting role for ROCK2 in tumors like gastric cancer  hepatocellular carcinoma  and osteosarcoma , and that ROCK2 inhibition produced beneficial effects.
In conclusion, there are many anti-aging strategies in development, some of which have shown considerable promise for slowing down aging or delaying the onset of age-related diseases. From multiple pre-clinical studies, it appears that upregulation of autophagy through autophagy enhancers, elimination of senescent cells using senolytics, transfusion of plasma from young blood, neurogenesis and BDNF enhancement through specific drugs are promising approaches to sustain normal health during aging and also to postpone age-related diseases. However, these approaches will require critical assessment in clinical trials to determ...