Cardiac amyloidosis: in search of the ideal diagnostic tool.

CONCLUSION: NT-proBNP may be a sensitive but nonspecific biomarker for assessing CA. However, CMR is the only imaging modality that can assess the pathophysiologic background of cardiac hypertrophy and the severity of CA, irrespective of NT-proBNP level. PMID: 31796976 [PubMed - as supplied by publisher]
Source: Herz - Category: Cardiology Tags: Herz Source Type: research

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Authors: Fauter M, Gerfaud-Valentin M, Delplanque M, Georgin-Lavialle S, Sève P, Jamilloux Y Abstract Adult-onset Still's disease (AOSD), first described in 1971 by Bywaters, is a rare systemic auto-inflammatory disorder of unknown etiology, characterized by a symptomatic triad associating prolonged fever, polyarthritis and rash. The management of this disease has significantly improved since its first description, and, although the overall prognosis of the AOSD is good, with a low attributable mortality, below 3% (but up to 18% depending on the series), some rare complications are still possible, can be lif...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
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Source: American Journal of Therapeutics - Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research
Conditions:   Cardiac Failure;   Coronary Artery Disease;   Sarcoidosis;   Amyloidosis;   Lupus;   Myocarditis;   Drug Toxicity Intervention:   Procedure: Diagnostic Test: Myostrain Sponsor:   University of Kansas Medical Center Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Porcari A, De Angelis G, Romani S, Paldino A, Artico J, Cannatà A, Gentile P, Pinamonti B, Merlo M, Sinagra G Abstract INTRODUCTION: Dilated cardiomyopathy (DCM) is generally thought as a final common pathway of several conditions that lead to the same clinical overt phenotype. Multiple imaging modalities play a fundamental role in recognizing the underlying pathological substrate leading to DCM. Areas covered: Echocardiography represents the first reliable and easily accessible diagnostic tool, allowing the identification of associated cardiac abnormalities, such as valve disease and highlighting f...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
Endomyocardial biopsy (EMB) is routinely performed for cardiac transplant monitoring. Moreover, it can be a useful tool in the diagnostic work-up of myocarditis, cardiomyopathies, drug toxicity, unexplained arrhythmias, heart involvement in systemic disease, and to diagnose cardiac masses. Pathologic evaluation of EMB represents the gold standard in specific disorders, including myocarditis and cardiac involvement by amyloidosis and sarcoidosis. To increase the diagnostic yield of the procedure, multiple myocardial samples should be obtained, and processed in a fully-equipped laboratory, with access to immunohistochemical/...
Source: Diagnostic Histopathology - Category: Pathology Authors: Tags: Mini-symposium: Cardiovascular pathology Source Type: research
Clinical application and technical considerations of T1 &T2(*) mapping in cardiac, liver, and renal imaging. Br J Radiol. 2018 Jul 05;:20180825 Authors: Dekkers IA, Lamb HJ Abstract Pathological tissue alterations due to disease processes such as fibrosis, edema and infiltrative disease can be non-invasively visualized and quantified by magnetic resonance imaging using T1 and T2 relaxation properties. Pixel-wise mapping of T1 and T2 image sequences enable direct quantification of T1, T2(*), and extra-cellular volume (ECV) values of the target organ of interest. Tissue characterization based on T1 ...
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
Conditions:   Dilated Cardiomyopathies;   Hypertrophic Cardiomyopathy;   Restrictive Cardiomyopathy;   Arrhythmogenic Right Ventricular Cardiomyopathy;   Myocarditis;   Sarcoidosis With Myocarditis;   Giant Cell Myocarditis;   Amyloidosis; Heart (Manifestation) Intervention:   Sponsors:   Göteborg University;   Sahlgrenska University Hospital, Sweden Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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