Study to Assess Safety and Effectiveness of Branebrutinib Treatment in Participants With Active Systemic Lupus Erythematosus or Primary Sj ögren's Syndrome, or Branebrutinib Treatment Followed by Open-label Abatacept Treatment in Study Participants With Active Rheumatoid Arthritis

Conditions:   Autoimmune Disorder;   Rheumatoid Arthritis;   Systemic Lupus Erythematosus;   Primary Sjögren's Syndrome Interventions:   Drug: branebrutinib;   Drug: abatacept;   Drug: branebrutinib placebo Sponsor:   Bristol-Myers Squibb Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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CARDIOVASCULAR CONSEQUENCES OF AUTOIMMUNE RHEUMATIC DISEASES. Curr Vasc Pharmacol. 2020 Jan 27;: Authors: Atzeni F, Nucera V, Gerratana E, Fiorenza A, Gianturco L, Corda M, Sarzi-Puttini P Abstract The increased risk of cardiovascular disease (CVD) among patients with autoimmune rheumatic dis-eases such as rheumatoid arthritis, spondyloarthritis and systemic lupus erythematosus has been exten-sively documented. Sub-clinical atherosclerosis can be assessed using various non-invasive imaging techniques. However, the mechanisms underlying the greater risk of atherosclerotic CVD in patients with autoimmun...
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research
CONCLUSIONS: The influence of traditional cardiovascular risk factors on cIMT and carotid plaque is similar in RA and SLE. PMID: 31969232 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Anti-microbial antibodies have been found useful for diagnosis of Crohn ’s disease (CD) and Sjogren’s syndrome (Sjo). These antibodies are also elevated in other autoimmune disease such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and multiple sclerosis (MS). The prevalence of these antibodies in the normal healthy population is unknown. We set t o survey the normal population for these anti-microbial antibodies in comparison with Crohn’s disease and others. Totally 288 blood samples from the donor units of the leukocyte-reduced red blood cells from the American Red Cross were examined...
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Diagnostics in IBD Source Type: research
CONCLUSION: Only the results of MR analysis by the IVW method indicated that periodontitis is likely causally associated with an increased risk of RA and SLE incidence. Our MR showed weak causal association between periodontitis and RA or SLE. These findings may assist in elucidating the underlying mechanisms of the effects of periodontitis on RA and SLE incidence. PMID: 31965238 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Tags: Z Rheumatol Source Type: research
One of the most important messages from the recent review is that diagnostic difficulty can occur as a result of clinical presentations of extrapulmonary tuberculosis that overlap with other conditions [1]. Conditions which can overlap with extrapulmonary manifestations of tuberculosis include extrapulmonary manifestations of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Immunoglobulin G4-Related Disease (IgG4-RD) and cryptococcal infection. In each of these disorders the extrapulmonary complications which occur may be indistinguishable from the extrapulmonary manifestations of tuberculosis.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
There is increasing recognition of the role the microbiome plays in states of health and disease. Microbiome studies in systemic autoimmune diseases demonstrate unique microbial patterns in Inflammatory Bowel Disease, Rheumatoid Arthritis, and Systemic Lupus Erythematosus to a lesser extent, whereas there is no single bug or pattern that characterizes Multiple Sclerosis. Autoimmune diseases tend to share a predisposition for vitamin D deficiency, which alters the microbiome and integrity of the gut epithelial barrier. In this review, we summarize the influence of intestinal bacteria on the immune system, explore the microb...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 20 January 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): Tatianna F.S. De Nardo, Paulo H.L. Bertolo, Priscila A. Bernardes, Danísio P. Munari, Gisele F. Machado, Luciana S. Jardim, Pamela R.R. Moreira, Mayara C. Rosolem, Rosemeri O. VasconcelosABSTRACTMacrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that is produced by many cell types in situations of homeostasis or disease. One of its functions is to act as a proinflammatory molecule. In humans, several studies have shown that MIF levels become elevated in the serum, urine, cerebrospinal flu...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
Abstract Methotrexate (MTX)-associated classical Hodgkin lymphoma (CHL) is unlikely to regress following discontinuation of MTX, and its treatment usually requires chemotherapy. Standard chemotherapy for CHL is the ABVD regimen, which contains pneumotoxic bleomycin. This can be problematic in MTX-CHL patients suffering from an autoimmune disease (AID), such as rheumatoid arthritis (RA), as they frequently have pulmonary complications. However, brentuximab vedotin (BV)-containing chemotherapy without bleomycin (A + AVD regimen) was recently reported to show favorable efficacy for CHL, and could therefore ...
Source: International Journal of Hematology - Category: Hematology Authors: Tags: Int J Hematol Source Type: research
We thank Dr. Jolobe for his insightful comments regarding our review “Tuberculosis: a focused review for the emergency medicine clinician” [1,2]. Dr. Jolobe highlighted several conditions that present similarly to tuberculosis (TB), including pleural effusion in a patient with previously diagnosed rheumatoid arthritis and systemic lupus erythematosus, pericardial effusion in a patient with previously diagnosed rheumatoid arthritis and systemic lupus erythematosus, immunoglobulin G4-related pleuropulmonary disease and tuberculous pleurisy, and disseminated tuberculosis in a patient with cryptococcal meningitis [1].
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
Robin shared her husband’s life-altering Wheat Belly experience: “I wanted to encourage those just starting out and getting through the difficult detox. If you are rethinking your decision, know that you are doing the best thing you could ever do for yourself and your family. “This is a picture of my husband, Kirk. He is 50 and had plans of having to go on disability this year due to the extreme pain in every joint in his body. Walking was extremely difficult. He works 10 hours a day in lawncare. We thought he had lupus or rheumatoid arthritis. Plus he suffered horrible gout attacks that would put him dow...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open autoimmune gluten-free grain-free Inflammation Weight Loss wheat belly Source Type: blogs
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