Middle longitudinal fascicle is associated with semantic processing deficits in primary progressive aphasia

In this study, 20 PPA patients and 25 healthy controls were recruited in the Primary Progressive Aphasia program in the Massachusetts General Hospital Frontotemporal Disorders Unit. We used diffusion tensor imaging (DTI) tractography to reconstruct the MdLF and extract tract-specific DTI metrics (fractional anisotropy (FA), radial diffusivity (RD), mean diffusivity (MD) and axial diffusivity (AD)) to assess white matter changes in PPA and their relationship with language impairments. We found severe WM damage in the MdLF in PPA patients, which was principally pronounced in the left hemisphere. Moreover, the WM alterations in the MdLF in the dominant hemisphere were significantly correlated with impairments in word comprehension and naming, but not with articulation and fluency. In addition, asymmetry analysis revealed that the DTI metrics of controls were similar for each hemisphere, whereas PPA patients had clear laterality differences in MD, AD and RD. These findings add new insight into the localization and severity of white matter fiber bundle neurodegeneration in PPA, and provide evidence that degeneration of the MdLF contribute to impairment in semantic processing and lexical retrieval in PPA.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research

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ConclusionRegardless of its rarity, it is evident that damage in the left SMA usually results in a clinical syndrome that clearly corresponds to aphasia. Interpreting this as an aphasia can aid in overcoming the limited idea of a “language zone” located in the perisylvian area of the left hemisphere, that was proposed over one century ago.
Source: Journal of Neurolinguistics - Category: Speech-Language Pathology Source Type: research
Too much going on for one post today.1. Sock puppet?We have a reader who is obsessed with his false conclusion that the commenter Don Quixote is actually my sock puppet. I ask you please to stop wasting your time and mine with this delusion. We do know each other, but we have seen each other once in the past 15 years or so. I live in Connecticut and he lives in the midwest, more than 1,000 miles away. Whatever I have to say, I am more than happy to say in my own name, and I do. BTW I am not known as Michael.2. Mad KingYour Intertubes are all aflutter with speculation and discussion about the neurodegenerative disease many ...
Source: Stayin' Alive - Category: American Health Source Type: blogs
CONCLUSIONS: An early multidisciplinary management of communicative-linguistic and swallowing functions is crucial in order to prevent adverse events and to plan a tailored rehabilitation pathway. PMID: 31868687 [PubMed - as supplied by publisher]
Source: NeuroRehabilitation - Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research
Publication date: February 2020Source: The Arts in Psychotherapy, Volume 67Author(s): Laura L. Wood, Dani Bryant, Kerryann Scirocco, Hia Datta, Susan Alimonti, Dave MowersAbstractAphasia, most often caused by brain damage due to stroke, is a language disorder hindering one's ability to verbally express and/or comprehend language, ranging in severity from mild to severe. An Applied Thematic Analysis (ATA) was undertaken of a post-production focus group to evaluate a 12-week pilot program that used the CoActive Therapeutic Theater (CoATT) Model for persons in Aphasia recovery. Results of a focus group interview found five th...
Source: Arts in Psychotherapy - Category: Psychiatry & Psychology Source Type: research
Conclusions: Lesion localization is the main factor that determines the characteristics of aphasic deficits. Etiology indirectly acts through a different sensitivity of the brain regions to various pathologies.
Source: Cognitive and Behavioral Neurology - Category: Neurology Tags: Original Studies Source Type: research
son C Abstract Assessment of language and cognitive abilities are associated with clinical challenges. The aim of the present study was to learn more about the MMSE test process from a language perspective by looking in detail at the interaction between patient and tester. In addition, we aimed to further explore the relationship between linguistic and cognitive difficulties.The study was based on an analysis of 20 MMSE test dyads, 10 persons with aphasia and 10 persons with dementia, in interaction with speech and language pathologists. All conversations were audio and video recorded and transcribed verbatim acco...
Source: Clinical Linguistics and Phonetics - Category: Speech-Language Pathology Authors: Tags: Clin Linguist Phon Source Type: research
In conclusion, FAS is a rare motor speech disorder, often related to cerebrovascular accidents involving critical regions in the dominant hemisphere. In addition, the present case adds further evidence to the role of the left primary motor cortex in modulation of prosody. In rare cases FAS can be the only sign of stroke or can appear after recovery from post-stroke aphasia.
Source: Neurological Sciences - Category: Neurology Source Type: research
Conclusions In the current study, AQ underestimated the presence of PPA and WAB-R classification did not distinguish among PPA classification determined by consensus. Performance on individual subtests and relative performance across subtests demonstrated inconsistent alignment with PPA classification. We conclude the WAB-R in isolation is inadequate to detect or characterize PPA. We instead suggest utilizing the WAB-R as 1 component of a comprehensive language and motor speech assessment when PPA is suspected. PMID: 31639312 [PubMed - as supplied by publisher]
Source: American Journal of Speech-Language Pathology - Category: Speech-Language Pathology Authors: Tags: Am J Speech Lang Pathol Source Type: research
Publication date: Available online 14 October 2019Source: NeuroImage: ClinicalAuthor(s): Robert Loughnan, Diego L. Lorca-Puls, Andrea Gajardo-Vidal, Valeria Espejo-Videla, Céline R. Gillebert, Dante Mantini, Cathy J. Price, Thomas M.H. HopeAbstractAround a third of stroke survivors suffer from acquired language disorders (aphasia), but current medicine cannot predict whether or when they might recover. Prognostic research in this area increasingly draws on datasets associating structural brain imaging data with outcome scores for ever-larger samples of stroke patients. The aim is to learn brain-behavior trends from ...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Conclusion: While patients with schizophrenia and aphasia showed language impairments, the nature and cognitive basis of these impairments may be different; language performance disassociates from broader cognitive functioning in aphasia but may be an intrinsic expression of a broader cognitive impairment in schizophrenia. Thought disorder may represent a core malfunction of grammatical processing. Results suggests that communicative ability may be a valid target in cognitive remediation strategies in schizophrenia. PMID: 31550981 [PubMed - as supplied by publisher]
Source: Cognitive Neuropsychiatry - Category: Psychiatry Tags: Cogn Neuropsychiatry Source Type: research
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