Stabilization of cardiac function with diflunisal in transthyretin (ATTR) cardiac amyloidosis

Transthyretin amyloidosis cardiomyopathy (ATTR-CM) is an underappreciated cause of heart failure that results from misfolded TTR (prealbumin) protein. Diflunisal is an approved non-steroidal anti-inflammatory drug (NSAID) that stabilizes TTR, with limited data available regarding effects on cardiac structure and function.

Source: Journal of Cardiac Failure - December 1, 2019 Category: Cardiology Authors: Graham Lohrmann, Alexandra Pipilas, Roberta Mussinelli, Deepa M. Gopal, John L. Berk, Lawreen H. Connors, Nirupama Vellanki, Jennifer Hellawell, Omar K. Siddiqi, Jonathan Fox, Mathew S. Maurer, Frederick L. Ruberg Source Type: research