Noise-induced changes in expression levels of NADPH oxidases in the cochlea.
Conclusion: Noise-induced up-regulation of NOX1 and DUOX2 could be linked to cochlear injury. In contrast, down-regulation of NOX3 may represent an endogenous protective mechanism to reduce oxidative stress in the noise-exposed cochlea. Inhibition of NADPH oxidases is potentially a novel pathway for therapeutic management of noise-induced hearing loss.
PMID: 23899412 [PubMed - as supplied by publisher]
Source: Hearing Research - Category: Audiology Authors: Vlajkovic SM, Lin SC, Yan Wong AC, Wackrow B, Thorne PR Tags: Hear Res Source Type: research