Dietary phenylalanine requirements during early and late gestation in healthy pregnant women.

CONCLUSIONS: Our results suggest a higher requirement (40%) for phenylalanine during late pregnancy than during early pregnancy. Moreover, the early pregnancy requirements are higher than the previous adult male requirement (9.1 mg · kg-1 · d-1; 95% CI: 4.6, 13.6 mg · kg-1 · d-1), although the 95% CIs overlap. Both DAAO and IAAO methods provided similar breakpoints in late pregnancy, showing that the DAAO method was appropriate even though low phenylalanine intakes could not be tested. These results have potential implications for gestation stage-specific dietary phenylalanine recommendations in future.This trial was registered at clinicaltrials.gov as NCT02669381. PMID: 31758682 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31758682?dopt=Abstract

Source: The American Journal of Clinical Nutrition - November 22, 2019 Category: Nutrition Authors: Ennis MA, Rasmussen BF, Lim K, Ball RO, Pencharz PB, Courtney-Martin G, Elango R Tags: Am J Clin Nutr Source Type: research