PK/PD models in antibacterial development.

PK/PD models in antibacterial development.
Curr Opin Microbiol. 2013 Jul 18;
Authors: Velkov T, Bergen PJ, Lora-Tamayo J, Landersdorfer CB, Li J
Abstract
There is an urgent need for novel antibiotics to treat life-threatening infections caused by bacterial 'superbugs'. Validated in vitro pharmacokinetic/pharmacodynamic (PK/PD) and animal infection models have been employed to identify the most predictive PK/PD indices and serve as key tools in the antibiotic development process. The results obtained can be utilized for optimizing study designs in order to minimize the cost and duration of clinical trials. This review outlines the key in vitro PK/PD and animal infection models which have been extensively used in antibiotic discovery and development. These models have shown great potential in accelerating drug development programs and will continue to make significant contributions to antibiotic development.
PMID: 23871724 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - July 18, 2013 Category: Microbiology Authors: Velkov T, Bergen PJ, Lora-Tamayo J, Landersdorfer CB, Li J Tags: Curr Opin Microbiol Source Type: research