Role of TLR2 Polymorphism (2258) in Susceptibility to Pulmonary Tuberculosis

TLR2 polymorphism is essential in the immune response to mycobacteria. It is a prospective association study based on the analysis of the distribution of alleles of a gene polymorphism between 250 adult patients and having a proven pulmonary tuberculosis and 250 controls healthy"T", and having a negative tuberculin IDR and normal chest x-ray. The mean age of the cases was 38.3+/-15.1 with a sex ratio of 1.45 while that of controls was 40.6 +/-13.4 with a sex ratio of 1.25. Matching by gender and age showed a significant difference (p <10-3) for the GG genotype and the G allele (OR> 2). The distribution of polymorphisms by sex found a significantly elevated frequency of GG genotype in "T" in comparison with patients of the same sex: male:-caseVs T:98.9% Vs98.2%,p = 0.0045, OR = 0.47, CI = 0.28-0.79.female:-cas Vs "T":100%Vs100%,p= 0.001, OR = 0.34, IC = 0.18-0.64. As well as for the allelic frequency (G) which shows a significant difference. The results show an association of TLR2 polymorphism with pulmonary tuberculosis, and suggest the existence of a gender-related role in its appearance. This difference can be explained by the role of sex hormones or by other factors not yet elucidated.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research