Pyrosequencing(PSQ) in early diagnosis of CNS tuberculosis and determining drug resistance

Conclusion: PSQ helps detecting MTB complex directly fromCSF even with negative Xpert. Early diagnosis, detection of resistance aids in administering appropriate treatment early and decrease mortality, long term disability. PSQ shows promising results in diagnosing, early detection of resistance in CNS TB. Though correlation with phenotypic DST recommended & further research warranted.

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Bhosle, A., Singhal, P., Pardasani, V., Lunia, P., Ajbani, K., Dhangar, D., Tiple, S. Tags: Tuberculosis Source Type: research