Exploration of breath analysis to monitor therapeutic response in mesothelioma patients

Background: Malignant pleural mesothelioma (MPM) is an aggressive cancer, with a five-year survival rate of
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pleural and mediastinal malignancies Source Type: research

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Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer, which originates from the mesothelial cells of the pleura and is associated with asbestos exposure. In light of its aggressive nature, late diagnosis and dismal prognosis, there is an urgent need for identification of biomarkers in easily accessible samples (such as blood) for early diagnosis of MPM. In the last 10 years, epigenetic markers, such as DNA methylation and microRNAs (miRNAs), have gained popularity as possible early diagnostic and prognostic biomarkers in cancer research. The aim of this review is to provide a critical analysis of the curren...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
The U.S. Environmental Protection Agency released an asbestos draft risk evaluation Monday that found serious health dangers to workers in the chloralkali industry, the country’s last remaining user of raw asbestos. There is an “unreasonable risk to workers, occupational non-users, consumers and bystanders” the EPA found when evaluating several asbestos products still being imported and used today. The draft risk evaluation was an initial review of asbestos by the EPA under the amended Toxic Substances Control Act (TSCA). “It is being disseminated for peer review purposes and is not final,” an...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Authors: van Zandwijk N, Reid G, Frank AL Abstract Introduction: Asbestos, the most frequent cause of occupational cancer, continues to be consumed on a massive scale, with millions of people exposed on a daily basis. This review explains why we have failed in curtailing the silent epidemic of asbestos-related disease and why the numbers of asbestos victims are likely to remain high. Emerging and developed countries have to be reminded that asbestos exposure has yet to become a problem of the past. The worldwide spread of asbestos, followed by the surge of asbestos-related cancers, resembles the lung cancer epidemi...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
Evidence continues to mount that prolonged exposure to cosmetic talcum powder contaminated by asbestos fibers is causing mesothelioma cancer. Individuals using cosmetic talc regularly may be putting themselves at higher risk, according to doctors at Peninsula Pathology Associates in Newport News, Virginia. They recently completed the most extensive case study to date on the topic. Mesothelioma is an aggressive cancer caused primarily by the inhalation or ingestion of asbestos fibers. Peninsula’s study involved 75 mesothelioma patients — including 64 women — who believed their only exposure to asbestos was...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
The authors regret that one author ’s name was written incorrectly, being S. Prince instead of S. Austin. It has been corrected in this corrigendum.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Tags: Corrigendum Source Type: research
The Florida Legislature has passed a bill designed to better protect its firefighters from cancer-causing contaminants, including toxic asbestos. By approving the legislation, Florida joined a growing number of states that have passed laws in recent years to help firefighters combat occupational hazards they face every day. The Firefighter Cancer Decontamination Equipment Grant Program in Florida will provide funding for departments to procure supplies, equipment and add additional training that should reduce exposure to hazardous pollutants. It includes all fire departments across the state, from large municipal entities...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Conditions:   Thoracic Cancer;   Non-small Cell Lung Cancer;   Small-cell Lung Cancer;   Pleural Mesothelioma Intervention:   Other: eRAPID online symptom monitoring in lung cancer Sponsors:   University of Leeds;   The Leeds Teaching Hospitals NHS Trust;   Iqvia Pty Ltd Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
As the U.S. comes to grips with the challenges of the COVID-19 pandemic, mesothelioma cancer survivors face additional hurdles, including difficulty receiving care. Patients currently undergoing treatment for cancer and those who are immunocompromised are at greater risk of serious health issues if they contract COVID-19, according to the Centers for Disease Control and Prevention. “Cancer patients are a high-risk group and should be extra vigilant in terms of isolation precautions. They should follow the medical authorities’ instructions,” Dr. Ory Wiesel, a thoracic surgeon at Maimonides Medical Center ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Malignant mesothelioma (MM), especially its more frequent form, malignant pleural mesothelioma (MPM), is a devastating thoracic cancer with limited therapeutic options. Recently, clinical trials that used immunotherapy strategies have yielded promising results, but the benefits are restricted to a limited number of patients. To develop new therapeutic strategies and define predictors of treatment response to existing therapy, better knowledge of the cellular and molecular mechanisms of MM tumors and sound preclinical models are needed. This review aims to provide an overview of our present knowledge and issues on both subj...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Raw asbestos imported to the United States dropped significantly in 2019, according to the recently released U.S. Geological Survey Mineral Commodity Summaries report. The U.S. imported an estimated 100 metric tons of asbestos last year. It’s the smallest amount since records were first kept in 1910, long before the mineral became a major part of the construction industry in America. That number is in sharp contrast to the 681 metric tons imported in 2018. All imported asbestos went to the chloralkali industry — for the second consecutive year — to use in the manufacturing of semipermeable diaphragms for ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
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