Drug resistance and HIV rates are high in Eastern European patients with Tuberculosis in a South East London Hospital

Conclusion: Young, male Eastern Europeans form a significant proportion of pulmonary INH-R/MDRTB/XDRTB, with high HIV and transfer of care rates. This may be representative of a working migrant population with a high risk of both initial and acquired TB resistance. Whole genome sequencing would help define this group further.Eastern European cohort (N=44)England 2016Europe 2016Male: Female2.31.41.5Site: Pulmonary36 (82%)54%76.3%HIV positive4/40 (10%)3.8%4.5%Positive microbiology/histology35 (80%)71%71%Drug susceptibility testing (n= 31)- INH- R- MDR/RR- XDR2 (6.4%)*1 (3.2%)*1 (3.2%)*5.5%1.7%0.2%-3.7%(20.1% of MDR were XDRCompleted treatment37 (84%)81%71.5%*all pulmonary

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Ratnakumar, S., Choon, X. Y., Belton, M., Palchaudhuri, P., Cotton, L. Tags: Tuberculosis Source Type: research