The characteristics of mycobacterioses in patients with chronic lung diseases
Aim: To determine the characteristics of chronic lung diseases in patients with mycobacterioses caused by slowly growing nontuberculous mycobacteria (NTM).We studied 51 patients with pulmonary mycobacterioses caused by slowly growing NTM; the average age was 54.1±0.3 yrs; disease duration was 19.5±0.5 months. In all patients the diagnosis was microbiologically verified. Out of them 25 (49%) were infected with M. avium, 21.5% – M. intracellulare, 9.8% – M. kansasii, 5.8% – M. xenopi, 3.9% – M. gordonae, 3.9% – M. lentiflavum. Four patients were co-infected with M. avium + M. intracellulare. We studied clinical and radiological patterns of mycobacterioses and concomitant lung diseases.According to HRCT, in 6 (11.7%) patients mycobacteriosis proceeded as a restricted form (a focus or a tuberculoma). In 45 (88.2%) it was associated with a chronic lung disease: in 25.9% – with chronic bronchitis and bronchiectasis; 20.7% – TB, 22.4% – COPD, 19% – bronchoectatic disease (BED) and cystic fibrosis, 6.9% – bronchial asthma (BA), 5.2% – chronic sarcoidosis, 3.4% – lung cancer, 3.4% – chemotherapy of other localizations cancer. In 10 (19.6%) patients we observed mycobacteriosis associated with more than one lung disease: TB+BED, COPD+BA, COPD+TB, COPD+BA +TB.Radiological patterns of mycobacterioses caused by slowly growing NTM were as follows: focal changes – 81.6%, bronchiectasis – 6...
ConclusionsUnlike [18F]FDG, [18F]BODIPY 1 showed prominent accumulation in BAT under both inactive and stimulated status. [18F]BODIPY 1 may serve as a valuable BAT PET agent to possibly assess BAT mitochondria density, thus BAT thermogenic capacity after further evaluation.
ConclusionsHypoxia modulation may play a role in nal-IRI ’s mechanism of action. Nal-IRI demonstrated greater anti-tumor activity in the more aggressive and hypoxic tumor model. Furthermore, hypoxia imaging provided early prediction of treatment response.
AbstractPurposeTo investigate and validate the potential role of a radiomics signature in predicting the side-specific probability of extracapsular extension (ECE) of prostate cancer (PCa).ProceduresThe preoperative magnetic resonance imaging data of 238 prostatic samples from 119 enrolled PCa patients were retrospectively assessed. The samples with were randomized in a two-to-one ratio into training (n = 74) and validation (n = 45) datasets. The radiomics features were derived from T2-weighted images (T2WIs). The optimal radiomics features were identified from the least absolute shrinkage and s...
ConclusionsIntegrated [68Ga]PSMA-11 PET/MRI provides a similarly high diagnostic performance for localization of recurrent PC as PET/CT. For the detection of local recurrences [68Ga]PSMA-11 PET/MRI is superior compared with [68Ga]PSMA-11 PET/CT.
Publication date: Available online 25 May 2020Source: Life SciencesAuthor(s): Serena L'Abbate, Ilaria Russo, Claudia Kusmic
PMID: 32448438 [PubMed - in process]
PMID: 32448437 [PubMed - in process]
Dear colleagues, please advise concerning this patient: 40 yo male, high PS, diagnosed a couple of years ago of colic cancer that was locally treated. Aug 2020: he was diagnosed of left parietal (at the level of the motor strip) solitary brain lesion. octobre 2020: he underwent a complete resection , followed by cavity SRS 18Gy /1 fr April 2020: refractory seizures MRI showed a relapsing left parietal cavity lesion, whose epicenter was next to the trolard vein. he was re-resected quasi... re-irradiation after single fraction cavity SRS? What dose?
Publication date: Available online 12 May 2020Source: The Journal of Molecular DiagnosticsAuthor(s): Manny D. Bacolod, Aashiq H. Mirza, Jianmin Huang, Sarah F. Giardina, Philip B. Feinberg, Steven A. Soper, Francis Barany
To observe the surgical index at the different learning stages of thoraco-laparoscopic esophagectomy in the prone position for esophageal cancer and to investigate the learning curve of this surgical procedure.