The characteristics of mycobacterioses in patients with chronic lung diseases

Aim: To determine the characteristics of chronic lung diseases in patients with mycobacterioses caused by slowly growing nontuberculous mycobacteria (NTM).We studied 51 patients with pulmonary mycobacterioses caused by slowly growing NTM; the average age was 54.1±0.3 yrs; disease duration was 19.5±0.5 months. In all patients the diagnosis was microbiologically verified. Out of them 25 (49%) were infected with M. avium, 21.5% – M. intracellulare, 9.8% – M. kansasii, 5.8% – M. xenopi, 3.9% – M. gordonae, 3.9% – M. lentiflavum. Four patients were co-infected with M. avium + M. intracellulare. We studied clinical and radiological patterns of mycobacterioses and concomitant lung diseases.According to HRCT, in 6 (11.7%) patients mycobacteriosis proceeded as a restricted form (a focus or a tuberculoma). In 45 (88.2%) it was associated with a chronic lung disease: in 25.9% – with chronic bronchitis and bronchiectasis; 20.7% – TB, 22.4% – COPD, 19% – bronchoectatic disease (BED) and cystic fibrosis, 6.9% – bronchial asthma (BA), 5.2% – chronic sarcoidosis, 3.4% – lung cancer, 3.4% – chemotherapy of other localizations cancer. In 10 (19.6%) patients we observed mycobacteriosis associated with more than one lung disease: TB+BED, COPD+BA, COPD+TB, COPD+BA +TB.Radiological patterns of mycobacterioses caused by slowly growing NTM were as follows: focal changes – 81.6%, bronchiectasis – 6...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research

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ConclusionsUnlike [18F]FDG, [18F]BODIPY 1 showed prominent accumulation in BAT under both inactive and stimulated status. [18F]BODIPY 1 may serve as a valuable BAT PET agent to possibly assess BAT mitochondria density, thus BAT thermogenic capacity after further evaluation.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
ConclusionsHypoxia modulation may play a role in nal-IRI ’s mechanism of action. Nal-IRI demonstrated greater anti-tumor activity in the more aggressive and hypoxic tumor model. Furthermore, hypoxia imaging provided early prediction of treatment response.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
AbstractPurposeTo investigate and validate the potential role of a radiomics signature in predicting the side-specific probability of extracapsular extension (ECE) of prostate cancer (PCa).ProceduresThe preoperative magnetic resonance imaging data of 238 prostatic samples from 119 enrolled PCa patients were retrospectively assessed. The samples with were randomized in a two-to-one ratio into training (n = 74) and validation (n = 45) datasets. The radiomics features were derived from T2-weighted images (T2WIs). The optimal radiomics features were identified from the least absolute shrinkage and s...
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
ConclusionsIntegrated [68Ga]PSMA-11 PET/MRI provides a similarly high diagnostic performance for localization of recurrent PC as PET/CT. For the detection of local recurrences [68Ga]PSMA-11 PET/MRI is superior compared with [68Ga]PSMA-11 PET/CT.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
Publication date: Available online 25 May 2020Source: Life SciencesAuthor(s): Serena L'Abbate, Ilaria Russo, Claudia Kusmic
Source: Life Sciences - Category: Biology Source Type: research
PMID: 32448438 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
PMID: 32448437 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
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Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums
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Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
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Source: Journal of Cardiothoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Research article Source Type: research
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