High-dose rifampicin in tuberculosis: experiences from a Dutch tuberculosis centre

Conclusion: High-dose R, used in specific groups of patients in our clinical setting, is safe and well-tolerated for the whole treatment duration. Measurement of drug exposures could be used as a tool/guide to increase R dosage if a reduced medication absorption or a poor treatment outcome is suspected. Pending the results from clinical trials, we suggest to administer high-dose R to patients with severe manifestations of TB or low R exposure to improve treatment outcome.

Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Seijger, C., Hoefsloot, W., Bergsma, I., Van Ingen, J., Kuijpers, S., Te Brake, L., Van Crevel, R., Aarnoutse, R., Boeree, M., Magis-Escurra, C. Tags: Tuberculosis Source Type: research