Rescue of infectious Arumowot virus from cloned cDNA: Posttranslational degradation of Arumowot virus NSs protein in human cells

This study showed an establishment of the first reverse genetics for AMTV, a lack of stability of AMTV NSs proteins in human cells, and an IFN-β gene antagonist function of AMTV NSs proteins in murine cells. The AMTV can be a nonpathogen ic surrogate model for studying phleboviruses including RVFV.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research