Engineering of antibacterial/recyclable difunctional nanoparticles via synergism of quaternary ammonia salt site and N-halamine sites on magnetic surface.

Engineering of antibacterial/recyclable difunctional nanoparticles via synergism of quaternary ammonia salt site and N-halamine sites on magnetic surface. Colloids Surf B Biointerfaces. 2019 Nov 12;:110642 Authors: Chen Y, Feng C, Zhang Q, Luo M, Xu J, Han Q Abstract A biocidal composite unit with improved synergism, using one cationic quaternary ammonia salt (QAS) site to attract electronegative bacteria to three highly biocidal N-halamine sites, was designed for the first time and attached onto surface of magnetic silica coated Fe3O4 nanoparticles (silica@Fe3O4NPs) for superior biocidability, large killing area, and easy recyclability. Briefly, a compound containing one imide and two amide NH bonds, 2-(2,5-dioxoimidazolidin-4-yl)-N-(4-hydroxyphenyl)acetamide (DHPA), was prepared by amidation of hydantoin acetic acid with p-aminophenol. A biocidal precursor of one QAS site and three N-halamine sites was then constructed by alcoholysis of 3-triethoxysilylpropyl succinic anhydride with 2-(dimethylamino)ethan-1-ol to introduce a tertiary amine and subsequent esterification with DHPA to introduce three NH bonds. The triethoxysilyl groups in the precursor were hydrolyzed to silanol groups to condense with their counterparts on silica@Fe3O4 NPs. The surface of resultant NPs carried units each contains one QAS site and three N-halamine sites after quaternization and chlorination. The biocidal surface showed superior biocidability against E...
Source: Colloids and Surfaces - Category: Biotechnology Authors: Tags: Colloids Surf B Biointerfaces Source Type: research