The Role of Chinese Herbal Medicine in the Management of Adverse Drug Reactions of Leflunomide in Treating Rheumatoid Arthritis

ConclusionThis review introduced that the adoption of CHM is emerging as a novel strategy for the management of ADRs caused by LEF.Graphical Abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research

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ConclusionMSUS is powerful in the detection of early RA regarding synovitis, joint effusion, tenosynovitis, and bone erosions, which were correlated with clinical and laboratory parameters.
Source: Academic Radiology - Category: Radiology Source Type: research
Women with rheumatoid arthritis (RA) who adhere to an ideal clinical pathway have similar pregnancy outcomes as women in the general population, new findings show.Reuters Health Information
Source: Medscape Orthopaedics Headlines - Category: Orthopaedics Tags: Rheumatology News Source Type: news
There are limited data regarding efficacy of abatacept treatment for rheumatoid arthritis (RA) outside clinical trials. Quality registers have been useful for observational studies on tumor necrosis factor inh...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
Rheumatoid Arthritis (RA) has been increasingly associated with perturbations to the microbial communities that reside in and on the body (the microbiome), in both human and animal studies. To date, such studies have mainly focused on the microbial communities that inhabit the gut and oral cavity. Mounting evidence suggests that microbial DNA can be detected in the blood circulation using a range of molecular methods. This DNA may represent an untapped pool of biomarkers that have the potential to report on changes to the microbiome of distant sites (e.g., example, the gut and oral cavity). To this end, through amplificati...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
In this study, we aim to investigate whether and whereby the oral microbiome communities alter prior to symptoms of RA. Seventy-nine saliva samples were collected from 29 high-risk individuals, who were positive for anti-citrullinated protein antibodies (ACPA) and have no clinical arthritis, 27 RA patients and 23 healthy controls (HCs). The salivary microbiome was examined using 16S ribosomal RNA gene sequencing. Alpha and beta diversity analysis and the linear discriminant analysis were applied to examine the bacterial diversity, community structure and discriminatory taxa between three groups, respectively. The correlati...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
CONCLUSION: Ultrasound could be as sensitive and specific as contrast-enhanced MRI for the diagnosis of subclinical synovitis and tenosynovitis.
Source: Clinics - Category: General Medicine Source Type: research
One of the most important messages from the recent review is that diagnostic difficulty can occur as a result of clinical presentations of extrapulmonary tuberculosis that overlap with other conditions [1]. Conditions which can overlap with extrapulmonary manifestations of tuberculosis include extrapulmonary manifestations of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Immunoglobulin G4-Related Disease (IgG4-RD) and cryptococcal infection. In each of these disorders the extrapulmonary complications which occur may be indistinguishable from the extrapulmonary manifestations of tuberculosis.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
There is increasing recognition of the role the microbiome plays in states of health and disease. Microbiome studies in systemic autoimmune diseases demonstrate unique microbial patterns in Inflammatory Bowel Disease, Rheumatoid Arthritis, and Systemic Lupus Erythematosus to a lesser extent, whereas there is no single bug or pattern that characterizes Multiple Sclerosis. Autoimmune diseases tend to share a predisposition for vitamin D deficiency, which alters the microbiome and integrity of the gut epithelial barrier. In this review, we summarize the influence of intestinal bacteria on the immune system, explore the microb...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 20 January 2020Source: Veterinary Immunology and ImmunopathologyAuthor(s): Tatianna F.S. De Nardo, Paulo H.L. Bertolo, Priscila A. Bernardes, Danísio P. Munari, Gisele F. Machado, Luciana S. Jardim, Pamela R.R. Moreira, Mayara C. Rosolem, Rosemeri O. VasconcelosABSTRACTMacrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that is produced by many cell types in situations of homeostasis or disease. One of its functions is to act as a proinflammatory molecule. In humans, several studies have shown that MIF levels become elevated in the serum, urine, cerebrospinal flu...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research
Source: Patient Preference and Adherence - Category: International Medicine & Public Health Tags: Patient Preference and Adherence Source Type: research
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