dsRNA induces IL-33 promoter activity through TLR3-EGFR-IRF3 pathway in normal human epidermal keratinocytes

IL-33 is a member of the IL-1 cytokine family and constitutively expressed in endothelial cells and epithelial cells exposed to stimuli. IL-33 was identified as a ligand of the IL-1 receptor family member ST2L. IL-33 activates group2 innate immune cells, mast cells, eosinophils, basophils, NKT cells, dendritic cells, and neutrophils [1]. IL-33 can enhance the Th2 immune reaction to promote cytokines, and it also functions as a nuclear factor to suppress or enhance NF- κB function [2]. Recent studies showed that IL-33 is involved in anti-viral reactions, such as airway infection with influenza virus or parainfluenza virus, and cutaneous infection with herpes simplex virus [3,4].

Source: Journal of Dermatological Science - November 18, 2019 Category: Dermatology Authors: Meijuan Jin, Mayumi Komine, Hidetoshi Tsuda, Tomoyuki Oshio, Mamitaro Ohtsuki Tags: Letter to the Editor Source Type: research