Qi-Wei-Du-Qi-Wan and its major constituents exert an anti-asthmatic effect by inhibiting mast cell degranulation

ConclusionThese results indicate that QWDQW plays a role in suppressing excessive airway reaction and in specific immune modulation in a mouse model of chronic asthma and that QWDQW suppresses mast cell degranulation at defined doses of quercetin, β-carotene and luteolin.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research

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ConclusionsCompared with Montelukast, CHMs were more effective and had less adverse effects in the treatment of CVA.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Authors: Chen LC, Zeng GS, Wu LL, Zi M, Fang ZK, Fan HZ, Yu HP Abstract Objective: To evaluate the diagnostic value of fractional exhaled nitric oxide (FeNO) and maximum mid-expiratory flow (MMEF) for differentiating cough variant asthma (CVA) from chronic cough in patients with or without allergic rhinitis.Methods: In total, 328 patients with chronic cough who underwent spirometry and FeNO testing were consecutively included in the retrospective analysis. Patients were divided into the CVA (n = 125) or NCVA (n = 203) groups according to the diagnostic criteria of CVA. Receiver operating...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
AbstractIntroductionWhether non ‐asthmatic eosinophilic bronchitis (NAEB) shows response to bronchodilator (RB) remains unclear.ObjectivesTo investigate the RB and its relationship with clinical and pathophysiological features in NAEB.MethodsFifty ‐one patients with NAEB were assigned in a 2:1 ratio to receive oral bambuterol hydrochloride (n=34, 10mg, once daily, for 3 days) or matched placebo (n=17) randomly, of whom 48 patients (32 with bronchodilator and 16 with placebo) completed the study. Sputum induction, spirometry and cough reflex sensitivity were measured. RB was considered when cough VAS score decreased 30%...
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
Discussion The respiratory system is a complex system. The upper airways must remain patient. The lower airways must interface with the vascular system. The musculoskeletal system must provide mechanical function and the central nervous system must provide overall control. Respiratory failure occurs when the overall system cannot support the body’s necessarily ventilation, oxygenation or both. Children are at higher risk of respiratory failure. They have few intrinsic lung parenchyma problems, but have very small airways that increase the airflow resistance by themselves but then have to contend with problems such as...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
CONCLUSIONS: HBoV can be detected alone and in co-infection respiratory samples of children with an acute respiratory tract infection. A cause-effect relationship between HBoV and respiratory infection is not clear, so further studies are needed to clarify this point. PMID: 31776891 [PubMed - as supplied by publisher]
Source: World Journal of Pediatrics : WJP - Category: Pediatrics Authors: Tags: World J Pediatr Source Type: research
In this study, we evaluated whether D. sophia water extract (DSWE) can alleviate airway inflammation and airway hyperresponsiveness (AHR) in the lungs of a murine asthma model. Female BALB/c mice were divided into five groups: normal controls, ovalbumin (OVA)-sensitized asthmatic mice, and OVA-sensitized mice treated with DSWE (2, 4, 8 g/day) by intraperitoneal injection. After sacrificing the mice, serum was collected to detect OVA-specific antibodies by ELISA, as well as bronchoalveolar lavage fluid (BALF) to detect cytokine levels. We also detected gene expression and histopathologically evaluated the lungs of asthmatic...
Source: The American Journal of Chinese Medicine - Category: Complementary Medicine Authors: Tags: Am J Chin Med Source Type: research
Conclusion: Dyspnoea, limited activity and cough were problems of most importance to patients with severe asthma. Few interventions have been tested in severe asthma that specifically target these symptoms, suggesting a need to develop new targeted approaches.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Nurses Source Type: research
Conclusions: Respiratory symptoms are associated with subsequent respiratory hospitalisations and death in individuals with preserved pulmonary function without known airway disease.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
Conclusions: Large proportions of chronic cough patients in this trial were diagnosed with GERD, asthma, or allergic rhinitis. Despite receiving treatment for these conditions, chronic cough for these subjects had persisted for over a decade.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Background: Diagnosis of exercise-induced symptoms (EIS) is not easy as different causes result in similar symptoms. We compared referral diagnosis from primary care physicians with diagnosis given in paediatric respiratory outpatient clinics.Method: The Swiss Paediatric Airway Cohort (SPAC) is a national cohort study recruiting children (
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric respiratory epidemiology Source Type: research
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