How T'reg-ulate healing of the injured spinal cord?

How T'reg-ulate healing of the injured spinal cord? Immunology. 2019 Dec;158(4):253-254 Authors: Milling S, Edgar JM Abstract Regulatory T cells (Tregs) are important for limiting inflammation-dependent damage in neural tissue. However, Tregs have also been shown to inhibit neural repair associated with type 2 (anti-inflammatory/wound healing) immune responses. Recently, it was demonstrated that Sirtuins, a family of proteins that contribute to the control of cellular responses to metabolic stimuli, influence the functions of Tregs. Specifically, SIRT4 was found to suppress the anti-neuroinflammatory activity of Tregs infiltrating the spinal cord following injury; when SIRT4 expression was genetically suppressed, Tregs made more anti-inflammatory factors, IL-10, FoxP3, and transforming growth factor beta (TGFβ). Thus, understanding how the SIRT4-Treg pathway can be manipulated could provide useful avenues to control both pathogenic and neuroprotective immune responses. PMID: 31729761 [PubMed - in process]
Source: Immunology - Category: Allergy & Immunology Authors: Tags: Immunology Source Type: research