LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p.

In conclusion, LHX2 regulates tumorigenesis and autophagy via mTOR in OS and is negatively regulated by miR-129-5p. Targeting the miR-129-5p/LHX2/mTOR axis therefore represents a novel therapeutic strategy for OS treatment. PMID: 31724536 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31724536?dopt=Abstract

Source: Aging - November 12, 2019 Category: Biomedical Science Authors: Song H, Liu J, Wu X, Zhou Y, Chen X, Chen J, Deng K, Mao C, Huang S, Liu Z Tags: Aging (Albany NY) Source Type: research