New AHA/ACC Performance and Quality Statement on Hypertension New AHA/ACC Performance and Quality Statement on Hypertension

Hypertension affects more than one third of US adults, but achieving adequate control remains elusive. A new document fine-tunes existing approaches and suggests new strategies.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Cardiology News Source Type: news

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In this study, we investigated the renal-protective effects of the bioactive peptide IF from alcalase potato protein hydrolysate in spontaneously hypertensive rat kidney. Sixteen-week-old spontaneously hypertensive rats were divided into three groups (n=6), and Sixteen-week-old Wistar Kyoto rats (n=6) served as the control group. The rats were administered IF and captopril via oral gavage for 8 weeks and then sacrificed, and their kidneys were harvested. The kidney sections from the rats treated with IF showed restoration of the structure of the glomerulus and Bowman’s capsule. The expression levels of Nrf2-mediated ...
Source: Food Research International - Category: Food Science Source Type: research
Authors: Oinonen L, Koskela J, Eräranta A, Tikkakoski A, Kähönen M, Niemelä O, Mustonen J, Pörsti I Abstract Purpose: The underlying causes of primary hypertension are not fully understood. Evidence on the relation of plasma calcium concentration with blood pressure (BP) is inconsistent and relies largely on studies utilizing office BP measurements in populations using cardiovascular drugs. In many studies adjustment for confounders was not optimal. In this cross-sectional study we examined the association of plasma total calcium concentration with the haemodynamic determinants of blood pre...
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Abstract Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is achieved by translocating K+ into cells and increasing urinary K+ excretion. Emerging data now indicate that the renal thiazide-sensitive NaCl cotransporter (NCC) is critically involved in this homeostatic kaliuretic response. This suggests that the early distal convoluted tubule (DCT) is a K+ sensor that can modify sodium (Na+) delivery to downstream segments to promote or limit K+ secretion. K+ sensing is mediated by the bas...
Source: Physiological Reviews - Category: Physiology Authors: Tags: Physiol Rev Source Type: research
CONCLUSIONS: Apatinib can improve the disease control rate of recurrent and metastatic cervical cancer when chemotherapy has failed, and the treatment is well tolerated. This represents that apatinib may be a new treatment option for metastatic cervical cancer patients. PMID: 31788992 [PubMed - as supplied by publisher]
Source: Journal of Gynecologic Oncology - Category: OBGYN Tags: J Gynecol Oncol Source Type: research
Publication date: February 2020Source: Phytochemistry, Volume 170Author(s): M. Micucci, C. Bolchi, R. Budriesi, M. Cevenini, L. Maroni, S. Capozza, A. Chiarini, M. Pallavicini, A. AngelettiAbstractHypertension has become the leading risk factor for worldwide cardiovascular diseases. Conventional pharmacological treatment, after both dietary and lifestyle changes, is generally proposed. In this review, we present the antihypertensive properties of phytocomplexes from thirteen plants, long ago widely employed in ethnomedicines and, in recent years, increasingly evaluated for their activity in vitro and in vivo, also in human...
Source: Phytochemistry - Category: Chemistry Source Type: research
Publication date: Available online 4 December 2019Source: Revista Clínica Española (English Edition)Author(s): Á. Torralba-Morón, J.M. Guerra-Vales, F.J. Medrano-Ortega, M.A. Navarro-Puerto, D. Lora-Pablos, I. Marín-León, E. Calderón-Sandubete, A. Gómez-de la CámaraAbstractBackground and objectivesHeart failure (HF) is a frequent condition that deteriorates quality of life and results in high morbidity and mortality. A considerable number of studies have been implemented in recent years to determine the factors that affect the prognosis of HF; however, few stud...
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
Conclusion(s)Childhood adiposity was associated with increased risk of pregnancy hypertension, with the association of childhood abdominal obesity independent of adult abdominal obesity. Women who were persistently overweight/obese or abdominally obese since childhood had the highest risk of pregnancy hypertension.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Albuminuria acts as a marker of progressive chronic kidney disease and as an indicator for initiation of hypertension treatment via modulation of the renin-angiotensin-aldosterone system with angiotensin receptor blockers or angiotensin-converting enzyme inhibitors. However, the true significance of albuminuria has yet to be fully defined. Is it merely a marker of underlying pathophysiology, or does it play a causal role in the progression of kidney disease? The answer remains under debate. In this issue of the JCI, Bedin et al. used next-generation sequencing data to identify patients with chronic proteinuria who had bial...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Publication date: December 2019Source: European Urology Supplements, Volume 18, Issue 12Author(s): Aleksander Khelaia
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
AbstractPrescribing cascades are where a drug adverse reaction is wrongly attributed to the emergence of a new condition, which leads to further drug prescribing. This promotes polypharmacy, adverse drug reactions and therapeutic burden. An example of a prescribing cascade is the co-prescribing of loop diuretics to treat the peripheral oedema caused by calcium channel blocker (CCB) drugs. Although well recognised, this is still a combination of medications taken by millions of people worldwide. CCBs have no prognostic benefit in heart failure and have an absolute risk increase for oedema of around 8 –18% (number need...
Source: Drugs and Aging - Category: Geriatrics Source Type: research
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