Risk of piperacillin-induced hemolytic anemia in patients with cystic fibrosis and antipseudomonal treatment: a prospective observational study.

CONCLUSION: Our prospective study indicates that piperacillin-induced ddab occur more frequently in patients with CF than previously suggested. The question related to the significance of piperacillin-dependent antibodies may reflect new aspects in this field. PMID: 31724753 [PubMed - as supplied by publisher]
Source: Transfusion - Category: Hematology Authors: Tags: Transfusion Source Type: research

Related Links:

Plastic bronchitis is a potentially fatal disorder characterized by the exudation of proteinaceous material and cells in the airways that leads to branching cast formation, which can be expectorated or lead to asphyxiation. Plastic bronchitis can appear as a complication after single-ventricle palliation. Other causes of plastic bronchitis that have been described include cystic fibrosis, sickle-cell anemia, asthma, and lymphangiomatosis. The underlying pathophysiology of plastic bronchitis seems to be abnormal pulmonary lymphatic perfusion, and the preferred treatment is embolization of the abnormal pulmonary lymphatic vessels (1).
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Letter to the Editor Source Type: research
Conclusion: Regardless of the results of the newborn screening tests, patients with symptoms supporting CF should be further evaluated. For the patients with intermediate sweat test results, genetic analysis should be performed for CF. As seen in our study, it should be kept in mind that IRT negativity may also occur in mutations that cause severe CF.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Cystic fibrosis Source Type: research
‘Prime editing’ more precise than Crispr-Cas9, but still needs time before use on humansScientists have raised fresh hopes for treating people with genetic disorders by inventing a powerful new molecular tool that, in principle, can correct the vast majority of mutations that cause human genetic diseases.The procedure, named “prime editing”, can mend about 89% of the 75,000 or so harmful mutations known to mangle the human genome and lead to conditions such as cystic fibrosis, sickle cell anaemia, and a nerve-destroying illness called Tay-Sachs disease.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Gene editing Genetics Biology Science Source Type: news
Funding Opportunity RFA-HD-20-021 from the NIH Guide for Grants and Contracts. The purpose of this RFA is to encourage studies on reproductive health, fertility and fertility preservation/treatment options in patients born with a serious chronic condition who can now expect to survive into adulthood healthy enough to consider their reproductive health and fertility options. The underlying pathophysiology of diseases such as sickle cell anemia, thalassemia, and cystic fibrosis, among others, and/or the cumulative effects of their treatment, can compromise reproductive health. This RFA encourages teams of scientists with ex...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Compared to the general population, patients of Ashkenazi Jewish descent have an increased risk of being genetic carriers for certain diseases, with an overall carrier rate ranging from 1 in 4 to 1 in 51. Therefore, the American College of Obstetricians and Gynecologists (ACOG) strongly recommends this population be offered carrier screening for four conditions: Tay Sachs, Cystic Fibrosis, Familial Dysautonomia, and Canavan Disease2. Some experts have advocated for a more comprehensive screening panel, and subsequently, ACOG recognized that screening for the following Jewish Genetic Diseases can be offered to patients: Blo...
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
Abstract Sickle cell disease afflicts millions of people worldwide and approximately 100,000 Americans. Complications are myriad and arise as a result of complex pathological pathways 'downstream' to a point mutation in DNA, and include red blood cell membrane damage, inflammation, chronic hemolytic anemia with episodic vaso-occlusion, ischemia and pain, and ultimately risk of cumulative organ damage with reduced patient lifespan. The National Heart, Lung, and Blood Institute's 2014 evidence-based guideline for sickle cell disease -management states additional research is needed before investigational curative the...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research
There is a question about what role race and wealth play in how much attention and funding the disease receives.
Source: NYT - Category: American Health Authors: Tags: Sickle Cell Anemia Preventive Medicine Blacks Cystic Fibrosis Discrimination Source Type: news
CONCLUSIONS: We were unable to draw any conclusions due to the lack of available data and trials. This review highlights the need for conducting and appropriate reporting, of high-quality randomised controlled trials investigating the effectiveness of various treatment modalities for dental and orthodontic complications in people with thalassaemia. PMID: 31425614 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: E-Poster Sessions Source Type: research
Publication date: Available online 24 May 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Giulia Breveglieri, Elisabetta D’Aversa, Lucia Carmela Cosenza, Effrossyni Boutou, Angeliki Balassopoulou, Ersi Voskaridou, Roberto Gambari, Monica BorgattiAbstractSickle Cell Anemia (SCA) is a monogenic hereditary disease caused by a single point mutation (βS) in the β globin gene resulting in an abnormal hemoglobin (HbS) that can polymerize within the erythrocytes, inducing their characteristic sickle shape. This causes hemolytic anemia and occlusive vessels for the most severe clinical status. Molecular anal...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
More News: Anemia | Antibiotic Therapy | Cystic Fibrosis | Hematology | Study