Homology modeling and molecular dynamics dimulation study of β carbonic anhydrase of Ascaris lumbricoides.

Homology modeling and molecular dynamics dimulation study of β carbonic anhydrase of Ascaris lumbricoides. Bioinformation. 2019;15(8):572-578 Authors: Yadav M, Khandelwal S Abstract Ascaris lumbricoides is the prevalent parasite causing ascariasis by infecting the human alimentary tract. This is common in the jejunum of small intestine. Therefore, it is of interest to describe the target protein β Carbonic Anhydrase involved in Ascariasis. Carbonic anhydrase (CAs, the metallo enzymes) is encoded by six evolutionary divergent gene families α, β,γ, δ, ζ, and η, which contain zinc ion in their catalytic active site. β-CA is found in plants, algae, fungi, bacteria, protozoans, arthropods, and nematodes and completely absent in vertebrate genomes. The absence of β-CA protein in vertebrate makes the enzyme an important target for inhibitory studies against helminthic infection. The sequence to function related information and 3D structure data for β-CA of Ascaris lumbricoides is not available. Hence, we modeled the 3D structure (using PRIME) for the molecular dynamics and simulation studies (using the Desmond of Schrodinger software) and interaction analysis (using STRING database). The β-CA protein found to be interacting with carbonic anhydrase protein family along with T27A3, alh13, mtp18, T22F3, gcy29 proteins. These results provide insights for the understanding of the functional and biological...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research

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This study provides baseline information for better understanding the status of parasitic infections in Palestine and compares their epidemiology between the West Bank and Gaza Strip. Appropriate control measures and health education directed to the public about preventive measures should be considered to raise awareness about parasitic infections to lower their incidences and burden in Palestine. PMID: 31769396 [PubMed - as supplied by publisher]
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Ascariasis is a neglected tropical disease that affects 800 million people worldwide. Whereas most people only experience light worm burden, some people experience heavy worm burdens even after several rounds ...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
AbstractNowadays, wildlife is one of the most important sources of zoonoses, and it is a major concern for public health. Nevertheless, little is known about the role of wildlife as a reservoir and source of infectious diseases in the past. South America presents a wide diversity of wildlife. In the south of the continent, Argentina shelters a large diversity of neotropical carnivores. Although the paleoparasitological studies on carnivores have been increasing in southern Argentina, most of the efforts have been focused in a handful of sites located in western Patagonia. In this paper, two coprolites of felid found in Cue...
Source: International Journal of Osteoarchaeology - Category: Science Authors: Tags: SPECIAL ISSUE PAPER Source Type: research
Abstract Parasitic diseases caused by helminths (ascariasis, hookworm, trichinosis, and schistosomiasis) and protozoa (Chagas, leishmaniasis, and amebiasis) are considered serious public health problems in developing countries. Additionally, there is a limited arsenal of anti-parasitic drugs in the current pipeline and growing drug resistance. Therefore, there is a clear need for the discovery and development of new compounds that can compete and replace these drugs that have been controlling parasitic infections over the last decades. However, this approach is highly resource-intensive, expensive and time-consumi...
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AbstractNowadays, wildlife is one of the most important sources of zoonoses, and it is a major concern for the public health. Nevertheless, little is known about the role of wildlife as a reservoir and source of infectious diseases in the past. South America presents a wide diversity of wildlife. In the south of the continent, Argentina shelters a large diversity of neotropical carnivores. Although the paleoparasitological studies on carnivores have been increasing in southern Argentina, most of the efforts have been focused in a handful of sites located in western Patagonia. In this paper, two coprolites of felid found in...
Source: International Journal of Osteoarchaeology - Category: Science Authors: Tags: SPECIAL ISSUE PAPER Source Type: research
Answer:Acanthamoebasp. cysts and trophozoite.Wow, I really enjoyed reading the comments on this case! If you haven't already, I encourage you all to ready the holiday tale ofAscaris suum(a.k.a.Ascaris lumbricoides) by Old One. The story confirmed my suspicions of why we see so many cases of human ascariasis in patients from the Midwestern United States who haven't traveled internationally. The pigs are loaded with them!The comments also nicely describe the differences between the cysts and trophozoites of the free-living amebae that most commonly cause human disease:Acanthamoebaspecies,Balamuthia mandrillaris,andNaegleria ...
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
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Source: Zeitschrift fur Gastroenterologie - Category: Gastroenterology Authors: Tags: Z Gastroenterol Source Type: research
Ascaris lumbricoides (roundworm) is the most common helminth infection globally and a cause of lifelong morbidity that may include allergic airway disease, an asthma phenotype. We hypothesize that Ascaris larval migration through the lungs leads to persistent airway hyperresponsiveness (AHR) and type 2 inflammatory lung pathology despite resolution of infection that resembles allergic airway disease. Mice were infected with Ascaris by oral gavage. Lung AHR was measured by plethysmography and histopathology with hematoxylin and eosin (H&E) and periodic acid-Schiff (PAS) stains, and cytokine concentrations were measured by u...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Fungal and Parasitic Infections Source Type: research
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