Postdoctoral Training Fellow in HPA function

Job title: Postdoctoral Training FellowLocation: The Francis Crick Institute, Midland Road, LondonContract: Fixed-term, 4 yearsFull timeSalary: Competitive with benefits, subject to skills and experienceVacancy ID:     012106 The closing date for applications is Sunday, 1st December at 23:30.Find out more and apply at www.crick.ac.uk/careers-study Role of median eminence glial cells for hypothalamo-pituitary axis functionality A postdoctoral research post funded by the MRC in the laboratory of Dr. Robin Lovell-Badge is now available. We are looking for a highly motivated scientist to identify the origin of pituitary deficiencies that develop in up to 50% of paediatric cancer survivors after cranial irradiation. Recent published work, and data obtained in our lab suggest that supporting glial cells are required in the median eminence, the structure where information between the hypothalamus and pituitary is exchanged, and that their destruction by irradiation may underline development of pituitary deficiencies. The aim of this project is to assess this hypothesis in mice and characterise the role of this cell population in the hypothalamo-pituitary axis, with a particular emphasis on the establishment of neuro-vascular connections.
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Authors: Shabataev V, Saadat SH, Elterman DS Abstract The two major long-term concerns associated with different options for the management of prostate cancer, (including surgery, radiotherapy, brachytherapy, cryotherapy, HIFU, etc.) include difficulties with lower urinary tract symptoms (LUTS) and/or erectile dysfunction. LUTS can be in the form of stress urinary incontinence (SUI), urge urinary incontinence (UUI), frequency/urgency, and/or voiding difficulties. While surgery is mostly associated with SUI and radiation mostly results in UUI, there can be an overlap. Incontinence rates after cryotherapy and high in...
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
Authors: Magee DE, Singal RK Abstract Our objective is to provide an up-to-date summary of current literature on the indications for androgen deprivation therapy (ADT), ways in which ADT is used, and the main side effects associated with its use. MEDLINE (Pubmed) was searched for relevant papers published from database inception to May 1, 2019 for studies evaluating the use of ADT and its associated adverse events. ADT is a mainstay in the treatment of prostate cancer and is used throughout the disease course. While predominantly used in the metastatic setting, ADT has a role in the treatment of localized disease a...
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
Authors: Law KW, Nguyen DD, Barkin J, Zorn KC Abstract Prostate cancer screening remains highly controversial in medicine. The College of Family Physicians of Canada currently endorses positions that recommend against prostate-specific antigen (PSA) screening in men of all ages, while the Canadian Urological Association recommends shared and informed decision making for PSA screening in men 50-70 years old. Unfortunately, these opposing stances have left Family Physicians responsible for interpreting the appropriate course of action for their patients. Recent studies demonstrating an increase in incidence of metast...
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
This article is categorized under: Biological Mechanisms> Metabolism Translational, Genomic, and Systems Medicine> Translational Medicine Biological Mechanisms> Cell Signaling
Source: Wiley Interdisciplinary Reviews: Systems Biology and Medicine - Category: Biomedical Science Authors: Tags: ADVANCED REVIEW Source Type: research
Contributors : Lu Xin ; Liu GuoqiangSeries Type : Expression profiling by arrayOrganism : Mus musculusMyeloid derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells with differentiation program partially blocked in pathological conditions such as cancer. Through inhibition of T cells especially cytotoxic T lymphocytes (CTLs), MDSCs play important tumor-promoting roles and maintain a state of immunological anergy and toleranceWe used microarrays to profile gene expression of Gr-MDSC and identified differentially altered genes under different drug treatment.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
In this study, a versatile reduced graphene oxide (rGO) based drug delivery system (DDS) was developed for... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/C9CC09712K, CommunicationWenna Guo, Zengzhen Chen, Longfei Tan, Xiangling Ren, Qiong Wu, Changhui Fu, Yongxing Du, Jun Ren, Xianwei Meng We design a multifunctional CDDP-VPA@ZrMOF-Cys-PEG nanoparticles (CVZP NPs) based on the properties of valproic acid (VPA) that can downregulate the expression of vascular endothelial growth factor (VEGF) to reduce the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
Active surveillance is a widely embraced option for men with low-risk prostate cancer who wish to avoid immediate therapy and its associated morbidity.1 Unfortunately, a number of these men will harbor more aggressive disease at diagnosis that will go unrecognized and the opportunity for curative therapy may be delayed or missed altogether. The advent of multiparametric MRI in the evaluation of these men has offered better initial risk stratification. A number of recent trials have demonstrated reasonable positive predictive value in the detection of clinically significant disease.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
In the present paper we reported the finding of bulbospongiosus muscle (BSM) histology in patients with bulbar urethral strictures. The histologic assessment of the blood vessels, the neural integrity and the BSM itself were analyzed. There were 2 groups of patients where tissue for analysis was harvested. The experimental group (the stricture group) with bulbar urethral stricture undergoing urethroplasty and the control group which were patients undergoing perineal urethrostomy such as hypospadias cripples, penile cancer, or infections.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
In this large retrospective review of over 11,000 prostate biopsies performed by over 125 urologists from 2000 to 2018, DeWitt-Foy et al reported an association between urologic oncology fellowship training (UOFT) and a higher incidence of positive prostate biopsy as well as a higher diagnostic yield of clinically significant prostate cancer (defined as Gleason sum ≥7) compared to non-UOFT physicians. UOFT was also associated with an increased utilization of MRI-guided fusion biopsy as well as a higher prevalence of adequate biopsy (defined as obtaining ≥12 cores).
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
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