Chitosan-Pluronic based Cu Nanocomposite Hydrogels for Prototype Antimicrobial Applications.

Chitosan-Pluronic based Cu Nanocomposite Hydrogels for Prototype Antimicrobial Applications.
Int J Biol Macromol. 2019 Nov 09;:
Authors: Jayaramudu T, Varaprasad K, Koteshwara Reddy K, Pyarasani RD, Akbari-Fakhrabadi A, Amalraj J
Abstract
Copper nanoparticles were synthesized via precipitation technique using the pseudonatural cationic chitosan biopolymer as a stabilizing agent. The nanoparticles developed were successfully incorporated into the 1:1 ratio of blended chitosan: pluronic F127 polymer solution and made their nanocomposite hydrogels by solution casting method. The formed copper-based nanocomposite hydrogels were characterized by using Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, scanning electron microscopy-energy dispersive spectroscopy and transmission electron microscopy studies. The antimicrobial activity of the fabricated nanocomposite hydrogels was tested via an inhibition zone process against both E. coli (gram-negative) and S. aureus (gram-positive) bacteria. The results conveyed that the copper-embedded chitosan-pluronic F127 nanocomposite hydrogels can be used effectively for antimicrobial applications as well as for wound care applications.
PMID: 31715225 [PubMed - as supplied by publisher]

Source: International Journal of Biological Macromolecules - November 8, 2019 Category: Biochemistry Authors: Jayaramudu T, Varaprasad K, Koteshwara Reddy K, Pyarasani RD, Akbari-Fakhrabadi A, Amalraj J Tags: Int J Biol Macromol Source Type: research