Imaging G-Ratio in Multiple Sclerosis Using High-Gradient Diffusion MRI and Macromolecular Tissue Volume FUNCTIONAL

BACKGROUND AND PURPOSE: Remyelination represents an area of great therapeutic interest in multiple sclerosis but currently lacks a robust imaging marker. The purpose of this study was to use high-gradient diffusion MRI and macromolecular tissue volume imaging to obtain estimates of axonal volume fraction, myelin volume fraction, and the imaging g-ratio in patients with MS and healthy controls and to explore their relationship to neurologic disability in MS. MATERIALS AND METHODS: Thirty individuals with MS (23 relapsing-remitting MS, 7 progressive MS) and 19 age-matched healthy controls were scanned on a 3T MRI scanner equipped with 300 mT/m maximum gradient strength using a comprehensive multishell diffusion MRI protocol. Macromolecular tissue volume imaging was performed to quantify the myelin volume fraction. Diffusion data were fitted to a 3-compartment model of white matter using a spheric mean approach to yield estimates of axonal volume fraction. The imaging g-ratio was calculated from the ratio of myelin volume fraction and axonal volume fraction. Imaging metrics were compared between groups using 2-sided t tests with a Bonferroni correction. RESULTS: The mean g-ratio was significantly elevated in lesions compared with normal-appearing WM (0.74 vs 0.67, P
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: FUNCTIONAL Source Type: research

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Publication date: Available online 21 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Anna M. Pietroboni, Francesca Schiano di Cola, Annalisa Colombi, Tiziana Carandini, Chiara Fenoglio, Laura Ghezzi, Milena A. De Riz, Fabio Triulzi, Elio Scarpini, Alessandro Padovani, Daniela GalimbertiAbstractBackgroundNeurodegeneration is present from the earliest stages of multiple sclerosis (MS) and is critically involved in MS related clinical disability. Aim of the present study was to assess the connection between amyloid burden and early cerebellar grey matter (GM) atrophy compared to early brain GM atrophy ...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 1 October 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Xiaodong Song, Dawei Li, Zhandong Qiu, Shengyao Su, Yan Wu, Jingsi Wang, Zheng Liu, Huiqing DongAbstractBackgroundCervical spinal cord atrophy (CSCA), which partly reflects the axonal loss in the spinal cord, is increasingly recognized as a valuable predictor of disease outcome. However, inconsistent results have been reported regarding the correlation of CSCA and clinical disability in multiple sclerosis (MS). The aim of this meta-analysis was to synthesize the available data obtained from 3.0-Tesla (3T) MRI scanner...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionThis is the first Egyptian study to show that infratentorial lesions, confluent brain lesions and T1 hypointense lesions are conventional MRI parameters that correlate with the degree of disability in Egyptian MS patients.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionWe found no indication of a prognostic value of WML shrinking in early MS patients. WML shrinking seems to be related to waning of acute inflammation.
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
AbstractChronic active and slowly expanding lesions with smouldering inflammation are neuropathological correlates of progressive multiple sclerosis pathology. T1 hypointense volume and signal intensity on T1-weighted MRI reflect brain tissue damage that may develop within newly formed acute focal inflammatory lesions or in chronic pre-existing lesions without signs of acute inflammation. Using a recently developed method to identify slowly expanding/evolving lesionsin vivo from longitudinal conventional T2- and T1-weighted brain MRI scans, we measured the relative amount of chronic lesion activity as measured by change in...
Source: Brain - Category: Neurology Source Type: research
The objective of this study was to compare the efficacy of fingolimod and teriflunomide in reducing disease activity in RRMS.MethodsThis multicenter, retrospective observational study was carried out with prospectively collected data from 15 centers. All consecutive RRMS patients treated with teriflunomide or fingolimod were included. Data for relapses, Expanded Disability Status Scale (EDSS) scores and brain magnetic resonance imaging (MRI) scans were collected. Patients were matched using propensity scores.Annualized relapse rates (ARR), disability accumulation, percentage of patients with active MRI and treatment discon...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
AbstractStudies comparing the effects of natalizumab and fingolimod in relapsing –remitting multiple sclerosis (RRMS) are limited. We aimed to compare natalizumab and fingolimod effects on clinical, neuropsychological, and MRI measures in RRMS patients after 2 years of treatment. RRMS patients starting natalizumab (n = 30) or fingolimod (n = 25) underwent neurologic, neuropsychological, and brain MRI assessments at baseline, month (M) 6, M12, and M24. Volumes of lesions, brain, gray matter (GM), white matter (WM), and deep GM were measured. Fifteen healthy controls (HC) were also scan...
Source: Neurotherapeutics - Category: Neurology Source Type: research
Multiple Sclerosis (MS) can be prevented by undergoing routine magnetic resonance imaging (MRI) tests, according to researchers from the Institute of Neurology in London. MS progression is difficult to predict as the disease manifests itself differently in every patient. In their study recently published in  Brain, the researchers ventured out to define the predictors of long-term disability outcomes by using clinically isolated syndrome (CIS), a first episode of neurological symptoms that can evolve into MS, as a baseline. They used MRI exams after a CIS diagnosis to anticipate the future of a patient ’s h...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
CONCLUSIONS: Previous linear, but not macrocyclic, gadolinium-based contrast agent administration is associated with higher relaxation rates in a dose-dependent manner. Higher relaxation in some regions is associated with cognitive impairment but not physical disability or fatigue in MS. The findings should be interpreted with care but encourage studies into gadolinium retention and cognition.
Source: American Journal of Neuroradiology - Category: Radiology Authors: Tags: PATIENT SAFETY Source Type: research
Publication date: Available online 23 July 2019Source: European Journal of RadiologyAuthor(s): Jialiang Fu, Xiaoya Chen, Yao Gu, Min Xie, Qiao Zheng, Jingjie Wang, Chun Zeng, Yongmei LiAbstractPurposeTo characterize the spatial patterns of functional connectivity(FC) changes of whole brain in RRMS with somatosensory disorder(RRMS-SS) and to investigate the correlation between abnormal FC and clinical scores.MethodsTwenty-six RRMS-SS patients and 23 healthy controls(HC) underwent resting-state functional magnetic resonance imaging(RS-fMRI) scanning. The clinical scores were collected including Expanded Disability Status Sco...
Source: European Journal of Radiology - Category: Radiology Source Type: research
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