Association between plasma trimethylamine N-oxide and neoatherosclerosis in patients with very late stent thrombosis

Publication date: Available online 11 November 2019Source: Canadian Journal of CardiologyAuthor(s): Yu Tan, Jinying Zhou, Chen Liu, Peng Zhou, Zhaoxue Sheng, Jiannan Li, Runzhen Chen, Li Song, Hanjun Zhao, Bo Xu, Runlin Gao, Hongbing YanAbstractBackgroundTrimethylamine N-oxide (TMAO) has been shown to promote the development of atherosclerosis. However, the relationship between plasma TMAO and neoatherosclerosis, an important underlying mechanism of very late stent thrombosis (VLST), is unknown.MethodsThis post hoc study investigated the association between TMAO and neoatherosclerosis in two independent cohorts. These included a control group of 50 healthy volunteers and a study cohort of 50 patients with VLST who presented with ST-segment elevation myocardial infarction and underwent optical coherence tomography examination. Of the 50 patients with VLST, 23 had neoatherosclerosis and 27 did not have neoatherosclerosis. Patients with neoatherosclerosis were further divided into two subgroups, including 14 patients with plaque rupture and 9 without plaque rupture.ResultsThe plasma TMAO levels, detected using mass spectrometry, were significantly higher in patients with VLST than in healthy individuals (median [interquartile range]: 2.50 [1.67-3.84] vs. 1.32 [0.86-2.44] μM; P
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research

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The objective of this study was to estimate the frequency and type of adverse events (AEs) among critically ill patients and identify patient and hospital factors associated with AEs and clinical and health care utilization consequences of AEs. Materials and Methods: This retrospective cohort study includes patients admitted to 30 intensive care units (ICUs) in Alberta, Canada from May 2014 to April 2017. The main outcome was AEs derived from validated ICD-10, Canadian code algorithms for 18 AEs. Estimates of the proportion and rate of AEs are presented. The association between documented AEs and patient (eg, age, sex, ...
Source: Medical Care - Category: Health Management Tags: Original Articles Source Type: research
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Source: Future Medicine: Regenerative Medicine - Category: Genetics & Stem Cells Authors: Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
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Hello and good day to all! I am a 4th year student at a decent canadian university (UofT St. george) and am hoping to apply to medicine next cycle. However i am really worried about my application because i have 0 research experience. I took a research opportunity course and was treated so badly that it made me hate research. I was hoping to present some of my stats and ask what you folks think. Any feedback would be sincerely appreciated. GPA: 4.0 MCAT: 519 (132/126/132/129). First time... WAMC?/school list help/should i retake mcat for cars?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: What Are My Chances? WAMC Medical Source Type: forums
CONCLUSION: This case demonstrates the possibility of arterial compression by an adjacent venous stent graft, especially in a patient with a thin habitus and a brachial-brachial arteriovenous graft. Detailed identification of the outflow vein anatomy before stent implantation is mandatory to avoid such a complication. PMID: 31825299 [PubMed - as supplied by publisher]
Source: The Journal of Vascular Access - Category: Surgery Tags: J Vasc Access Source Type: research
Publication date: Available online 11 December 2019Source: Academic RadiologyAuthor(s): Adam Bernheim, Joel Grunhut, Alex Tang, Ekramul Gofur, Janice Thai, Varun Mehta, Jonathan Stern, Nima Jadidi, Adam Hodes, Bernard Goldwasser, Amrita Arneja, David Krausz, Michael Coords, Steven Peti, Jerel Chacko, David SarkanyRationale and ObjectivesTo evaluate if incidental abdominopelvic calcified atherosclerosis (ACA) in patients under 50 years of age correlates with cardiovascular disease (CVD) risk factors. Most studies evaluating calcific atherosclerosis and associated increased risk of CVD have concentrated on middle age and old...
Source: Academic Radiology - Category: Radiology Source Type: research
Bugs play a large role in our life. Bugs can be either good, or bad for us. Microorganisms, such as gut microbiota, are usually beneficial to us. They provide a barrier to pathogenic organisms and help to digest our food. However, microbiota also produce Trimethylamine-N-oxide (TMAO), a metabolite of dietary phosphatidylcholine and L-carnitine, that has been recently been shown to increase the risk of arterial thrombotic events, such as myocardial infarction and stroke. In this issue of Thrombosis Research, Reiner and colleagues have investigated whether plasma levels of TMAO also associate with recurrent venous thromboemb...
Source: Thrombosis Research - Category: Hematology Authors: Source Type: research
Gut microbiota-dependent trimethylamine-N-oxide (TMAO) correlates with arterial thrombotic events including myocardial infarction and stroke, and mortality. However, the association of TMAO with recurrent venous thromboembolism (VTE) and mortality remains unknown.
Source: Thrombosis Research - Category: Hematology Authors: Tags: Full Length Article Source Type: research
r U Abstract OBJECTIVE: Gut microbiota-dependent metabolites, in particular trimethylamine N-oxide (TMAO), have recently been reported to promote atherosclerosis and thrombosis. Here, we examined for the first time the relation of TMAO and the risk of incident cardiovascular events in patients with recent first-ever ischemic stroke in 2 independent prospective cohorts. Moreover, the link between TMAO and proinflammatory monocytes as a potential contributing factor for cardiovascular risk in stroke patients was studied. APPROACH AND RESULTS: In a first study (n=78), higher TMAO plasma levels were linked with a...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research
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