Clinical Translation of Pluripotent Stem Cell Therapies: Challenges and Considerations.

Clinical Translation of Pluripotent Stem Cell Therapies: Challenges and Considerations. Cell Stem Cell. 2019 Nov 07;25(5):594-606 Authors: Desgres M, Menasché P Abstract Although the clinical outcomes of cell therapy trials have not met initial expectations, emerging evidence suggests that injury-mediated tissue damage might benefit from the delivery of cells or their secreted products. Pluripotent stem cells (PSCs) are promising cell sources primarily because of their capacity to generate stage- and lineage-specific differentiated derivatives. However, they carry inherent challenges for safe and efficacious clinical translation. This Review describes completed or ongoing trials of PSCs, discusses their potential mechanisms of action, and considers how to address the challenges required for them to become a major therapy, using heart repair as a case study. PMID: 31703770 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31703770?dopt=Abstract

Source: Cell Stem Cell - November 6, 2019 Category: Stem Cells Authors: Desgres M, Menasché P Tags: Cell Stem Cell Source Type: research