Investigating microstructural variation in the human hippocampus using non-negative matrix factorization

Publication date: Available online 9 November 2019Source: NeuroImageAuthor(s): Raihaan Patel, Christopher J. Steele, Anthony Chen, Sejal Patel, Gabriel A. Devenyi, Jürgen Germann, Christine L. Tardif, M. Mallar ChakravartyAbstractIn this work we use non-negative matrix factorization to identify patterns of microstructural variance in the human hippocampus. We utilize high-resolution structural and diffusion magnetic resonance imaging data from the Human Connectome Project to query hippocampus microstructure on a multivariate, voxelwise basis. Application of non-negative matrix factorization identifies spatial components (clusters of voxels sharing similar covariance patterns), as well as subject weightings (individual variance across hippocampus microstructure). By assessing the stability of spatial components as well as the accuracy of factorization, we identified 4 distinct microstructural components. Furthermore, we quantified the benefit of using multiple microstructural metrics by demonstrating that using three microstructural metrics (T1-weighted/T2-weighted signal, mean diffusivity and fractional anisotropy) produced more stable spatial components than when assessing metrics individually. Finally, we related individual subject weightings to demographic and behavioural measures using a partial least squares analysis. Through this approach we identified interpretable relationships between hippocampus microstructure and demographic and behavioural measures. Taken tog...
Source: NeuroImage - Category: Neuroscience Source Type: research

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Conclusion: The development of LRSS pneumatization affects the removal rate of CS tumors in PAs. Preoperative analysis of LRSS development should be considered when planning EES against PA with CS invasion. PMID: 31819816 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Conclusion: Medically fragile patients with significant cervical spondylotic myelopathy but major comorbidities precluding major surgery successfully underwent MI cervical decompressions. PMID: 31819813 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Conclusion: GCTs were thought to be benign tumors with slow growth, but they could potentially possess aggressive features and invade into surrounding structures as described in this case. OTE can be a rare MRI finding of GCTs. Only one case of GCT-related OTE has been reported in literature to our best knowledge. PMID: 31819811 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
We describe an extremely rare case of SFT in the left preauricular region. The tumor lesion had gradually grown without pain or facial paralysis. Magnetic resonance imaging scan showed a circumscribed mass with high signal intensity on Gd-DTPA-enhanced T1-weighted images measuring approximately 3.0 cm in diameter. The tumor lesion was excised completely. Histological examination of the surgical specimen revealed proliferation of spindle tumor cells with a patternless pattern. Various amounts of collagen bundles intervened in the spindle tumor cells. The cellular atypia of the tumor cells was weak. Immunohistochemical studi...
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - Category: ENT & OMF Source Type: research
CONCLUSIONS: The results of this study suggest that the vascular imaging should be included in the assessment of disease activity in TAK. PMID: 31820717 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Livshetz I, Meghpara MB, Karam JA, Salem HS, Mont MA, Hassan OT, Goldberg BA Abstract INTRODUCTION: The tibial tubercle-trochlear groove (TT-TG) distance is commonly used to evaluate and guide treatment for patellar instability. There is limited data available regarding TT-TG variability based on patient demographics and anthropometric factors. MATERIALS AND METHODS: TT-TG was measured on magnetic resonance imaging (MRI) for 384 consecutive adult patients. Demographic information for the corresponding was then gathered from the medical record and analyzed. Demographic variables analyzed included age, s...
Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
CONCLUSIONS: 82RbCl PET produces high-contrast uptake of both recurrent disease and radiation necrosis compared to normal brain. However, no statistically significant difference was found between recurrent tumor and radiation necrosis. PMID: 31820882 [PubMed - as supplied by publisher]
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research
Publication date: Available online 11 December 2019Source: NeuroImageAuthor(s): Kenneth Wengler, Xiang He, Anissa Abi-Dargham, Guillermo HorgaAbstractNeuromelanin-sensitive MRI (NM-MRI) provides a noninvasive measure of the content of neuromelanin (NM), a product of dopamine metabolism that accumulates with age in dopamine neurons of the substantia nigra (SN). NM-MRI has been validated as a measure of both dopamine neuron loss, with applications in neurodegenerative disease, and dopamine function, with applications in psychiatric disease. Furthermore, a voxelwise-analysis approach has been validated to resolve substructure...
Source: NeuroImage - Category: Neuroscience Source Type: research
Publication date: Available online 11 December 2019Source: NeuroImageAuthor(s): Thomas A.W. Bolton, Valeria Kebets, Enrico Glerean, Daniela Zöller, Jingwei Li, B.T. Thomas Yeo, César Caballero-Gaudes, Dimitri Van De VilleAbstractThe impact of in-scanner motion on functional magnetic resonance imaging (fMRI) data has a notorious reputation in the neuroimaging community. State-of-the-art guidelines advise to scrub out excessively corrupted frames as assessed by a composite framewise displacement (FD) score, to regress out models of nuisance variables, and to include average FD as a covariate in group-level analys...
Source: NeuroImage - Category: Neuroscience Source Type: research
ConclusionsManagement of delivery in cases of suspected autosomal recessive renal polycystic kidney disease needs to be discussed because of the risk of abdominal dystocia. The route and timing of delivery depend on the size of the fetal abdominal circumference and the gestational age. The rate of kidney growth must also be taken into account.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
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