Intrinsically Distinct Role of Neutrophil Extracellular Trap Formation in Antineutrophil Cytoplasmic Antibody –Associated Vasculitis Compared to Systemic Lupus Erythematosus

ConclusionThe morphologic features, kinetics, induction pathways, and composition of excessive NET formation are all intrinsically distinct in AAV compared to SLE. Recognizing the diversity of NET formation between AAV and SLE provides a better understanding of the pathophysiologic role of NETs in these different autoimmune diseases.

Source: Arthritis and Rheumatology - November 8, 2019 Category: Rheumatology Authors: Laura S. Dam,, Tineke Kraaij, Sylvia W. A. Kamerling, Jaap A. Bakker,, Uli H. Scherer,, Ton J. Rabelink, Cees Kooten,, Y. K. Onno Teng Tags: Original Article Source Type: research