Antifungal Activity of Mammalian Serum amyloid A1 against Candida albicans.

Antifungal Activity of Mammalian Serum amyloid A1 against Candida albicans.
Antimicrob Agents Chemother. 2019 Nov 04;:
Authors: Gong J, Wu J, Ikeh M, Tao L, Zhang Y, Bing J, Nobile CJ, Huang G
Abstract
Mammalian serum amyloid A (SAA) is a major acute phase protein that shows a massive increase in plasma concentration during inflammation. In the current study, we demonstrate that the expression of mouse SAA1 in serum was increased when infected with Candida albicans, a major human fungal pathogen, in a systemic infection model. We then set out to investigate the antifungal activity of SAA proteins against C. albicans. Recombinant human and mouse SAA1 (rhSAA1 and rmSAA1) were expressed and purified in E. coli. Both rhSAA1 and rmSAA1 exhibited a potent antifungal activity against C. albicans. We further demonstrate that rhSAA1 binds to the cell surface of C. albicans, disrupts cell membrane integrity and induces rapid fungal cell death in C. albicans Our finding expands the known functions of SAA1 and provides new insight into host-Candida interactions during fungal infection.
PMID: 31685470 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - November 3, 2019 Category: Microbiology Authors: Gong J, Wu J, Ikeh M, Tao L, Zhang Y, Bing J, Nobile CJ, Huang G Tags: Antimicrob Agents Chemother Source Type: research