Antiphospholipid Antibody Syndrome and Infertility

The objective of the present study was to review the pathophysiology of APS and its association with female infertility. A bibliographic review of articles of the past 20 yearswas performed at the PubMed, Scielo, and Bireme databases. Antiphospholipid antibody syndrome may be associated with primary infertility, interfering with endometrial decidualization and with decreased ovarian reserve. Antiphospholipid antibodies also have direct negative effects on placentation, when they bind to the trophoblast, reducing their capacity for invasion, and proinflammatory effects, such as complement activation and neutrophil recruitment, contributing to placental insufficiency, restricted intrauterine growth, and fetal loss. In relation to thrombosis, APS results in a diffuse thrombotic diathesis, with global and diffuse dysregulation of the homeostatic balance. Knowing the pathophysiology of APS, which is closely linked to female infertility, is essential for new therapeutic approaches, specialized in immunomodulation andinflammatory signaling pathways, to provide important advances in its treatment.Resumo A S índrome do anticorpo antifosfolípide (SAF) é uma doença sistêmica, autoimune e prótrombótica caracterizada por anticorpos antifosfolípides, trombose, aborto recorrente, complicações durante a gestação, e, ocasionalmente, trombocitopenia. O objetivo do presente estudo foi revisar a fisiop atologia da...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research

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CONCLUSION: The analysis of the presence of 5T polymporphism in CBAVD patients may add information when predicting the outcome of assisted reproductive techniques. PMID: 31797807 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
Today's open access research on tryptophan and its role in age-related immune dysfunction is particularly interesting in the context of ongoing research into the changes that take place in gut microbiota with age. Other recent work has examined the way in which tryptophan production by gut microbes declines precipitously with age, as this is one of a number of compounds produced by bacteria, such as butyrate, indole, and proprionate, that are influential on long term health. It is a slow process, but researchers are uncovering the specific mechanisms linking age-related changes in gut microbe populations with declining hea...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Publication date: Available online 5 December 2019Source: Joint Bone SpineAuthor(s): Marie-Christophe Boissier, Jérome Biton, Luca Semerano, Patrice Decker, Natacha BessisABSTRACTWhile the exact cause of rheumatoid arthritis is unknown, several mechanisms have been described extensively. The genetic predisposition for this autoimmune disease is largely attributed to MHC class II genes, especially the main polymorphism in the HLA shared epitope. Non-genetic factors account for the rest. The best known are autoantigens to citrullinated or carbmylated proteins, although there are many others. They are recognized by an ...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
ConclusionAs with all human studies, population sampling and study design matter. Heterogeneity of inclusion and diagnostic criteria and selection bias overwhelmingly account for variability in endometriosis prevalence estimated across the literature. Thus, it is difficult to conclude if the lack of observed change in frequency and distributions of endometriosis over the past 30 years is valid.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Publication date: Available online 5 December 2019Source: Gynecologic Oncology ReportsAuthor(s): LB Lipi, L Philp, AK GoodmanAbstractHydatidiform mole coexisting with a normal live fetus in a twin pregnancy is extremely rare. Management of these cases is challenging due to the risk of severe antepartum and post-partum complications. Herein, we report the case of a 24-year-old gravida 2 para 1 who presented at 28 weeks gestation with severe preeclampsia, vulvar edema and a serum β-HCG of 285,000 IU /mL. Ultrasonography demonstrated a single live intra-uterine pregnancy with concurrent hydatidiform mole. Conservative ma...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
ConclusionsA better understanding of food cravings may assist with the development of interventions to improve eating behaviors and reduce eating-related distress during pregnancy. Acceptance regarding food cravings was indicated as a way to diffuse pregnancy-related stress. These findings contribute to our understanding of psychological influences on eating behaviors in pregnant women.
Source: Journal of the Academy of Nutrition and Dietetics - Category: Nutrition Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
We report our surgical approach to SAEF consisting in removal of the infected graft and in situ reconstruction using an autologous venous graft.Seven consecutive patients with SAEF treated with graft removal and in situ reconstruction using an autologous venous graft from 2008 to 2017 were reviewed. Six of seven patients (86%) survived 30-day. In one case a graft thrombosis and acute lower limb ischemia occurred requiring re-operations. All patients received injective antibiotic therapy for 20 days, followed by oral therapy for 3 months. There were no major complications at long-term follow-up.Our results suggest that supe...
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Publication date: Available online 5 December 2019Source: The Lancet HIVAuthor(s): Dvora Joseph Davey, Landon Myer, Thomas Coates
Source: The Lancet HIV - Category: Infectious Diseases Source Type: research
Publication date: Available online 5 December 2019Source: The Lancet HIVAuthor(s): John Kinuthia, Jillian Pintye, Felix Abuna, Kenneth K Mugwanya, Harison Lagat, Dickens Onyango, Emily Begnel, Julia Dettinger, Jared M Baeten, Grace John-Stewart, Ajode C Aquino, Steve J Ochieng, Alice M Lipesa, Ambia L Naidu, Anastacia Kamau, Anne W Njoroge, Bernard O Okeah, Cecilia B Makabwa, Celestine C Atieno, Christine K IreriSummaryBackgroundPregnant women in settings with high HIV prevalence are at increased risk of HIV acquisition and subsequent vertical transmission. We implemented and evaluated a novel programme to provide pre-expo...
Source: The Lancet HIV - Category: Infectious Diseases Source Type: research
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