Interaction of novel Aurora kinase inhibitor MK-0457 with human serum albumin: Insights into the dynamic behavior, binding mechanism, conformation and esterase activity of human serum albumin

This study is beneficial for understanding the biological action of MK-0457, providing additional information about the feasibility of its transport and accumulation in blood plasma.Graphical abstractIn-vitro assessment of the binding properties of MK-0457, a novel Aurora kinase inhibitor, with human serum albumin: computer simulations in combination with multi-spectroscopic, esterase activity and microscopic studies.
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research